Reymond Research Group

Check out our latest paper Exploring the Sequence Space of Antimicrobial Peptide Dendrimers in Israel Journal of Chemistry! Abstract There is an urgent need to develop new antibacterial agents against multidrug resistant bacteria. Herein we report our investigation of antimicrobial peptide dendrimers (AMPDs) active against Gram-negative bacteria, whose sequences were

Check out our latest paper Multistep retrosynthesis combining a disconnection aware triple transformer loop with a route penalty score guided tree search in Chemical Science! Abstract Computer-aided synthesis planning (CASP) aims to automatically learn organic reactivity from literature and perform retrosynthesis of unseen molecules. CASP systems must learn reactions sufficiently

Check out our latest paper Alchemical analysis of FDA approved drugs in Digital Discovery! Abstract Chemical space maps help visualize similarities within molecular sets. However, there are many different molecular similarity measures resulting in a confusing number of possible comparisons. To overcome this limitation, we exploit the fact that tools

RDKit is an important Open-Source Cheminformatics and Machine Learning tool that has been frequently used in the cheminformatics field. This year's RDKit User Group Meeting will take place from 20-22 September in-person in Mainz, Germany. The meeting will livestream the presentations for people who can only attend remotely.

The SCS Fall Meeting 2023 will take place on 24-25th of August at University of Bern! The SCS Fall Meeting is the major regularly organized event of the Swiss Chemical Society and one of the largest annual research conferences in Switzerland. For decades, the SCS Fall Meeting has been a

Check out our latest paper To Fold or Not to Fold: Diastereomeric Optimization of an α-Helical Antimicrobial Peptide in Journal of Medicinal Chemistry! Abstract Membrane disruptive α-helical antimicrobial peptides (AMPs) offer an opportunity to address multidrug resistance; however, most AMPs are toxic and unstable in serum. These limitations can be

The Reymond Research Group would like to welcome its new group member: Leon Rebhan (Ph.D. Student).

Check out our latest paper Inverse Polyamidoamine (i-PAMAM) Dendrimer Antimicrobials in Helvetica Chimica Acta by Etienne Bonvin! We redesigned polyamidoamine dendrimers by moving the carbonyl across the amide nitrogen to form inverse PAMAMs. Our i-PAMAMs are pure by HPLC, stable, and show potent antibacterial effects. https://doi.org/10.1002/

Reymond Group Networking Symposium took place successfully on Friday, March 24th! We are happy to see everyone, including some of our former group members in this great group reunion!

Reymond Group Networking Symposium is taking place on Friday 24.03.2023 in Gemeinschaftshörsaal! Everyone is welcome, don´t miss out! Zoom link: https://unibe-ch.zoom.us/j/65933453540?pwd=bkdiNDFNNkp6NUMwUjduaGJWZDFjQT09

The paper Synthesis and characterisation of fluorescent substrates for eukaryotic protein N-glycosylation is now available online in Tetrahedron! Check it out: https://www.sciencedirect.com/science/article/pii/S0040402023001436 Keywords: Carbohydrates; Fluorescence; Dolichol; Chitobiose; Mannose; Protein glycosylation Abstract: Herein we report the synthesis of two fluorescently labelled analogues of C25

The Reymond Research Group would like to welcome its new group member: Matheus Andrade Meirelles (Post-Doctoral Researcher).

A warm welcome to the Reymond group to Maedeh Darsaraee! Maedeh is starting a PhD in the exciting field of Machine Learning and Chemoinformatics.

The Reymond Research Group would like to welcome its new group member: Yves Grandjean (Ph.D. Student).

The paper Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis is now published in ACS Omega! Check it out: Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis Abstract: Herein, we report dipropylamine (DPA) as a fluorenylmethyloxycarbonyl (Fmoc) deprotection reagent to

Our paper Molecular Framework Analysis of the Generated Database GDB-13s (Ye Buehler and Jean-Louis Reymond, J. Chem. Inf. Model., 2023, 63, 2, 484-492, doi.org/10.1021/acs.jcim.2c01107) has been chosen to be featured on the cover of the January issue of Journal of Chemical Information and Modeling.

Our paper Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase is published in Nature Chemical Biology! Abstract: C-linked glycosylation is essential for the trafficking, folding and function of secretory and transmembrane proteins involved in cellular communication processes. The tryptophan C-mannosyltransferase (CMT) enzymes that install the modification attach a mannose to

We currently have an open PhD position in our group! Details can be found here.

The Reymond group wishes you a Merry Christmas and a Happy New Year 2023! Illustration: Artistic AI image generated by Midjourney, using a figure from our published paper: Molecular Framework Analysis of the Generated Database GDB-13s, Ye Buehler and Jean-Louis Reymond, J. Chem. Inf. Model., 2022 https://pubs.acs.org/

Three projects within the interdisciplinary network National Center of Competence in Research (NCCR) TransCure contributed by our group are now published in CHIMIA, archived in Vol. 76 No. 12 (2022): NCCR TransCure - Excellence in Membrane Transport Research 2010-2022! NCCR TransCure, funded by the Swiss National Science Foundation and the

The paper on Bemis and Murcko molecular frameworks of GDB-13s molecules is now published in JCIM! Here we assessed the originality of GDB and found out that many exclusive molecular frameworks in GDB might be the most relevant targets for synthetic chemistry aiming at innovative molecules. Check it out: Molecular