Reymond Research Group

University of Bern



369. TurboID mapping reveals the exportome of secreted intrinsically disordered proteins in the transforming parasite Theileria annulata Francis Brühlmann, Carmen Perry, Charlotte Griessen, Kapila Gunasekera, Jean-Louis Reymond, Arunasalam Naguleswaran, Sven Rottenberg, Kerry Woods, Philipp Olias, American Society for Microbiology, 2024,

368. One Chiral Fingerprint to Find Them All Markus Orsi and Jean-Louis Reymond, Journal of Cheminformatics, 2024,

367. Can Large Language Models Predict Antimicrobial Peptide Activity and Toxicity? Markus Orsi and Jean-Louis Reymond, RSC Medicinal Chemistry, 2024, 15, 2030 - 2036,

366. Overcoming Protein Orientation Mismatch Enables Efficient Nanoscale Light-Driven ATP Production Andrea Marco Amati, Stefan Urs Moning, Sacha Javor, Sandra Schär, Sabina Deutschmann, Jean-Louis Reymond, and Christoph von Ballmoos, ACS Synthetic Biology, 2024,

365. Submonomer Synthesis of Inverse Polyamidoamine (i-PAMAM) Dendrimer Antibacterials Hippolyte Personne, Xiaoling Hu, Etienne Bonvin, Jérémie Reusser and Jean-Louis Reymond, Helvetica Chimica Acta, 2024,

364. Highly Potent Cationic Chitosan Derivatives Coupled to Antimicrobial Peptide Dendrimers to Combat Pseudomonas Aeruginosa Olivier Jordan, Bee-Ha Gan, Sari Alwan, Karl Perron, Emmanuelle Sublet, Verena Ducret, Hua Ye, Gerrit Borchard, Jean-Louis Reymond and Viorica Patrulea, Advanced Healthcare Materials, 2024,


363. Antimicrobial Peptide–Peptoid Hybrids with and without Membrane Disruption Etienne Bonvin, Hippolyte Personne, Thierry Paschoud, Jérémie Reusser, Bee-Ha Gan, Alexandre Luscher, Thilo Köhler, Christian Van Delden, and Jean-Louis Reymond, ACS Infectious Diseases, 2023,

362. Optimizing phosphate couplings for dolichyl diphosphochitobiose to enable protein N-glycosylation studies Matheus A.Meirelles and Jean-Louis Reymond, Helvetica Chimica Acta, 2023,

361. Expanding Bioactive Fragment Space with the Generated Database GDB-13s Ye Buehler and Jean-Louis Reymond, J. Chem. Inf. Model., 2023, 63, 20, 6239–6248,

360. Exploring the Sequence Space of Antimicrobial Peptide Dendrimers Xingguang Cai, Alice Capecchi, Basak Olcay, Markus Orsi, Sacha Javor, and Jean-Louis Reymond, Isr. J. Chem., 2023,

359. Multistep retrosynthesis combining a disconnection aware triple transformer loop with a route penalty score guided tree search David Kreutter and Jean-Louis Reymond, Chem. Sci., 2023,

358. Alchemical analysis of FDA approved drugs Markus Orsi, Daniel Probst, Philippe Schwaller, and Jean-Louis Reymond, RSC Digital Discovery, 2023,

357. Organic Catalytic Activity as a Method for Agnostic Life Detection Christos D. Georgiou, Christopher McKay, and Jean-Louis Reymond, Astrobiology, 2023,

356. To Fold or Not to Fold: Diastereomeric Optimization of an α-Helical Antimicrobial Peptide Hippolyte Personne, Thierry Paschoud, Sofia Fulgencio, Stéphane Baeriswyl, Thilo Köhler, Christian van Delden, Achim Stocker, Sacha Javor, and Jean-Louis Reymond, J. Med. Chem., 2023,

355. Inverse Polyamidoamine (i-PAMAM) Dendrimer Antimicrobials Etienne Bonvin, and Jean-Louis Reymond, Helv. Chim. Acta, 2023, e202300035,

354. Synthesis and characterisation of fluorescent substrates for eukaryotic protein N-glycosylation Mario M. de Capitani, Ana S. Ramírez, Lorenzo Rossi, J. Andrew, N. Alexander, Sabrina De Lorenzo, Kaspar P. Locher, and Jean-Louis Reymond, Tetrahedron, 2023,

353. Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis Hippolyte Personne, Thissa N. Siriwardena, Sacha Javor, and Jean-Louis Reymond, ACS Omega, 2023, doi/10.1021/acsomega.2c07861

352. Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase Joël S. Bloch, Alan John, Runyu Mao, Somnath Mukherjee, Jérémy Boilevin, Rossitza N. Irobalieva, Tamis Darbre, Nichollas E. Scott, Jean-Louis Reymond, Anthony A. Kossiakoff, Ethan D. Goddard-Borger and Kaspar P. Locher, Nat. Chem. Biol., 2023,

351. Molecular Framework Analysis of the Generated Database GDB-13s Ye Buehler and Jean-Louis Reymond, J. Chem. Inf. Model., 2023, 63, 2, 484-492,


350. Vitaport: A Learning and Artistic Path for Public Outreach on Transporter Biology, Health and Drug Discovery Valentina Rossetti and Jean-Louis Reymond, Chimia, 2022, 76, 1063,

349. Physiological and Molecular Function of the Sodium/Hydrogen Exchanger NHA2 (SLC9B2) Tin Manh Ho, Stephan Berger, Philipp Müller, Céline Simonin, Jean-Louis Reymond, Christoph von Ballmoos and Daniel G. Fuster, Chimia, 2022, 76, 1019,

348. Molecular Similarity for Drug Discovery, Target Prediction and Chemical Space Visualization Jean-Louis Reymond, Chimia, 2022, 76, 1045,

347. An intrinsically disordered antimicrobial peptide dendrimer from stereorandomized virtual screening Xingguang Cai, Markus Orsi, Alice Capecchi, Thilo Köhler, Christian van Delden, Sacha Javor, and Jean-Louis Reymond, Cell Rep. Phys. Sci., 2022, 3, 101161,

346. Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase Ana S. Ramírez, Mario de Capitani, Giorgio Pesciullesi, Julia Kowal, Joël S. Bloch, Rossitza N. Irobalieva, Jean-Louis Reymond, Markus Aebi & Kaspar P. Locher, Nat. Commun., 2022, 13, 7296,

345. Medium-Chain Lipid Conjugation Facilitates Cell-Permeability and Bioactivity Johannes Morstein, Alice Capecchi, Konstantin Hinnah, ByungUk Park, Jerome Petit-Jacques, Reid C. Van Lehn, Jean-Louis Reymond and Dirk Trauner, J. Am. Chem. Soc., 2022, 144, 40, 18532–18544,

344. Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening Di Zhu, Sandra Johannsen, Tiziana Masini, Céline Simonin, Jörg Haupenthal, Boris Illarionov, Anastasia Andreas, Mahendra Awale, Robin M. Gierse, Tridia van der Laan, Ramon van der Vlag, Rita Nasti, Mael Poizat, Eric Buhler, Norbert Reiling, Rolf Müller, Markus Fischer, Jean-Louis Reymond and Anna Hirsch, Chem. Sci., 2022,

343. Machine Learning Guided Discovery of Non-Hemolytic Membrane Disruptive Anticancer Peptides Elena Zakharova, Markus Orsi, Alice Capecchi, Jean-Louis Reymond, ChemMedChem, 2022, e202200291,

342. Rotavirus Spike Protein VP4 Mediates Viroplasm Assembly by Association to Actin Filaments Janine Vetter, Guido Papa, Michael Seyffert, Kapila Gunasekera, Giuditta De Lorenzo, Mahesa Wiesendanger, Jean-Louis Reymond, Cornel Fraefel, Oscar R. Burrone, Catherine Eichwald, Journal of Virology, 2022, e01074-22,

341. Automatic Extraction of Reaction Templates for Synthesis Prediction Amol Thakkar and Jean-Louis Reymond, Chimia, 2022, 76, 294,

340. Reaction Classification and Yield Prediction using the Differential Reaction Fingerprint DRFP Daniel Probst, Philippe Schwaller and Jean-Louis Reymond, RSC Digital Discovery, 2022, 1, 91-97,

339. Synergistic effects of antimicrobial peptide dendrimer-chitosan polymer conjugates against Pseudomonas aeruginosa Viorica Patrulea, Bee-Ha Gan, Karl Perron, Xingguang Cai, Philippe Abdel-Sayed, Emmanuelle Sublet, Verena Ducret, Natalia Porroche Nerhot, Lee Ann Applegate, Gerrit Borchard, Jean-Louis Reymond, Olivier Jordan, Carbohydrate Polymers, 2022, 280, 119025,


338. Classifying natural products from plants, fungi or bacteria using the COCONUT database and machine learning Alice Capecchi, Jean-Louis Reymond, Journal of Cheminformatics, 2021, 13(1), 1-11,

337. An Immunomodulatory Peptide Dendrimer Inspired from Glatiramer Acetate Dina Erzina, Alice Capecchi, Sacha Javor and Jean-Louis Reymond, Angewandte Chemie, 2021, 60, 26403–26408,

336. A mixed chirality α-helix in a stapled bicyclic and a linear antimicrobial peptide revealed by X-ray crystallography Stéphane Baeriswyl, Hippolyte Personne, Ivan Di Bonaventura, Thilo Köhler, Christian van Delden, Achim Stocker, Sacha Javor and Jean-Louis Reymond, RSC Chemical Biology, 2021, 2, 1608-1617,

335. Inhibitors of human divalent metal transporters DMT1 (SLC11A2) and ZIP8 (SLC39A8) from a GDB-17 fragment library Jonai Pujol-Giménez, Marion Poirier, Sven Bühlmann, Céline Schuppisser, Rajesh Bhardwaj, Mahendra Awale, Ricardo Visini, Sacha Javor, Matthias A. Hediger, Jean-Louis Reymond, ChemMedChem, 2021, 16(21), 3306-3314, doi:10.1002/cmdc.202100467

334. Peptide Dendrimers: From Enzyme Models to Antimicrobials and Transfection Reagents Jean-Louis Reymond, Chimia, 2021, 75(6), 535-538, doi:10.2533/chimia.2021.535

333. Antimicrobial Peptide Dendrimers and Quorum-Sensing Inhibitors in Formulating Next-Generation Anti-Infection Cell Therapy Dressings for Burns Paris Jafari, Alexandre Luscher, Thissa Siriwardena, Murielle Michetti, Yok-Ai Que, Laurence G. Rahme, Jean-Louis Reymond, Wassim Raffoul, Christian Van Delden, Lee Ann Applegate and Thilo Köhler, Molecules, 2021, 26(13), 3839, doi:10.3390/molecules26133839

332. Machine learning designs non-hemolytic antimicrobial peptides Alice Capecchi, Xingguang Cai, Hippolyte Personne, Thilo Köhler, Christian van Delden and Jean-Louis Reymond, Chem. Sci., 2021, 12, 9221-9232, doi:10.1039/D1SC01713F

331. Predicting Enzymatic Reactions with a Molecular Transformer David Kreutter, Philippe Schwaller and Jean-Louis Reymond, Chem. Sci., 2021, 12, 8648-8659, doi:10.1039/D1SC02362D

330. Substrate specificities and reaction kinetics of the yeast oligosaccharyltransferase isoforms Jillianne Eyring, Chia-Wei Lin, Elsy Mankah Ngwa, Jérémy Boilevin, Giorgio Pesciullesi, Kaspar P.Locher, Tamis Darbre, Jean-Louis Reymond and Markus Aebi, J. Biol. Chem., 2021, 296, doi:10.1016/j.jbc.2021.100809

329. Medicinal Chemistry and Chemical Biology in the Age of the Pandemic Jean-Louis Reymond, Yves P. Auberson, Fides Benfatti and Cornelia Zumbrunn, Chimia, 2021, 225-226(2), doi:10.2533/chimia.2021.225

328. Prediction of chemical reaction yields using deep learning Philippe Schwaller, Alain C. Vaucher, Teodoro Laino and Jean-Louis Reymond, Mach. Learn.: Sci. Technol., 2021, 2(1), 015016, doi:10.1088/2632-2153/abc81d

327. The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4 Xingguang Cai, Sacha Javor, Bee Ha Gan, Thilo Köhler and Jean-Louis Reymond, Chem. Commun., 2021, 57, 5654-5657, doi:10.1039/D1CC01838H

326. Extraction of organic chemistry grammar from unsupervised learning of chemical reactions Philippe Schwaller, Benjamin Hoover, Jean-Louis Reymond, Hendrik Strobelt and Teodoro Laino, Sci. Adv., 2021, 7(15), eabe4166, doi:10.1126/sciadv.abe4166

325. Peptides in chemical space Alice Capecchi, Jean-Louis Reymond, Med. Drug Discovery, 2021, 9, 100081, doi:10.1016/j.medidd.2021.100081

324. Mapping the space of chemical reactions using attention-based neural networks Philippe Schwaller, Daniel Probst, Alain C. Vaucher, Vishnu H. Nair, David Kreutter, Teodoro Laino and Jean-Louis Reymond, Nat. Mach. Intell., 2021, 3(2), 144-152, doi:10.1038/s42256-020-00284-w

323. Retrosynthetic accessibility score (RAscore) – rapid machine learned synthesizability classification from AI driven retrosynthetic planning Amol Thakkar, Veronika Chadimová, Esben Jannik Bjerrum, Ola Engkvist and Jean-Louis Reymond, Chem.Sci., 2021, 12, 3339-3349, doi:10.1039/D0SC05401A

322. Stereorandomization as a Method to Probe Peptide Bioactivity Thissa N. Siriwardena, Bee-Ha Gan, Thilo Köhler, Christian van Delden, Sacha Javor and Jean-Louis Reymond, ACS Cent. Sci., 2021, 7(1), 126-134, doi:10.1021/acscentsci.0c01135

321. Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides Haneen Daralnakhla, Osama Saher, Susanna Zamolo, Safa Bazaz, Jeremy P. Bost, Marc Heitz, Karin E. Lundin, Samir EL Andaloussi, Tamis Darbre, Jean-Louis Reymond, Rula Zainand C. I. Edvard Smith, Pharmaceuticals, 2021, 13(1), 116, doi:10.3390/pharmaceutics13010116


320. Synergistic Effect of Propidium Iodide and Small Molecule Antibiotics with the Antimicrobial Peptide Dendrimer G3KL against Gram-Negative Bacteria Bee-Ha Gan, Xingguang Cai, Sacha Javor, Thilo Köhler and Jean-Louis Reymond, Molecules, 2020, 25(23), 5643, doi:10.3390/molecules25235643

319. Inactivation-mimicking block of the epithelial calcium channel TRPV6 Rajesh Bhardwaj, Sonja Lindinger, Arthur Neuberger, Kirill D. Nadezhdin, Appu K. Singh, Micael R. Cunha, Isabella Derler, Gergely Gyimesi, Jean-Louis Reymond, Matthias A. Hediger, Christoph Romanin, Alexander I. Sobolevsky, Sci. Adv., 2020, 6(48), eabe1508, doi:10.1126/sciadv.abe1508

318. AiZynthFinder: a fast, robust and flexible open-source software for retrosynthetic planning Samuel Genheden, Amol Thakkar, Veronika Chadimová, Jean-Louis Reymond, Ola Engkvist and Esben Bjerrum, J. Cheminformatics, 2020, 12(1), 1-9, doi:10.1186/s13321-020-00472-1

317. Artificial Intelligence and Automation in Computer Aided Synthesis Planning Amol Thakkar, Simon Johansson, Kjell Jorner, David Buttar, Jean-Louis Reymond and Ola Engkvist, React. Chem. Eng., 2020, 6, 27-51, doi:10.1039/D0RE00340A

316. What can reaction databases teach us about Buchwald–Hartwig cross-couplings? Martin Fitzner, Georg Wuitschik, Raffael J. Koller, Jean-Michel Adam, Torsten Schindlera and Jean-Louis Reymond, Chem. Sci., 2020, 11, 13085-13093, doi:10.1039/d0sc04074f

315. Assigning the Origin of Microbial Natural Products by Chemical Space Map and Machine Learning Alice Capecchi and Jean-Louis Reymond, Biomolecules, 2020, 10(10), 1385, doi:10.3390/biom10101385

314. A Potent and Selective Janus Kinase Inhibitor with a Chiral 3D‐Shaped Triquinazine Ring System from Chemical Space Kris Meier, Josep Arús-Pous and Jean-Louis Reymond, Angew. Chem. Int. Ed., 2020, 60, 2074-2077, doi:10.1002/anie.202012049

313. Transfer learning enables the molecular transformer to predict regio- and stereoselective reactions on carbohydrates Giorgio Pesciullesi, Philippe Schwaller, Teodoro Laino and Jean-Louis Reymond, Nat. Commun., 2020, 11(1), 1-8, doi:10.1038/s41467-020-18671-7

312. Transfecting tissue models with CRISPR/Cas9 plasmid DNA using peptide dendrimers Susanna Joelle Zamolo, Tamis Darbre and Jean-Louis Reymond, ChemComm, 2020, 56, 11981-11984, doi:10.1039/x0xx00000x

311. Natural product inspired optimization of a selective TRPV6 calcium channel inhibitor Micael Rodrigues Cunha, Rajesh Bhardwaj, Aline Lucie Carrel, Sonja Lindinger, Christoph Romanin, Roberto Parise-Filho, Matthias A. Hediger and Jean-Louis Reymond, RSC Med. Chem., 2020, 11, 1032-1040, doi:10.1039/D0MD00145G

310. One molecular fingerprint to rule them all: drugs, biomolecules, and the metabolome Alice Capecchi, Daniel Probst and Jean-Louis Reymond, J. Cheminformatics, 2020, 12(1), 1-15, doi:10.1186/s13321-020-00445-4

309. Fluorescent Peptide Dendrimers for siRNA Transfection: Tracking pH Responsive Aggregation, siRNA Binding, and Cell Penetration Marc Heitz, Susanna Zamolo, Sacha Javor and Jean-Louis Reymond, Bioconjugate Chem., 2020, 31(6), 1671-1684, doi:10.1021/acs.bioconjchem.0c00231

308. Pyrazolyl-pyrimidones inhibit the function of human solute carrier protein SLC11A2 (hDMT1) by metal chelation Marion Poirier, Jonai Pujol-Giménez, Cristina Manatschal, Sven Bühlmann, Ahmed Embaby, Sacha Javor, Matthias A. Hediger and Jean-Louis Reymond, RSC Med. Chem., 2020, 11, 1023-1031, doi:10.1039/D0MD00085J

307. SMILES-Based Deep Generative Scaffold Decorator for De-Novo Drug Design
Josep Arús-Pous, Atanas Patronov, Esben Jannik Bjerrum, Christian Tyrchan, Jean-Louis Reymond, Hongming Chen, Ola Engkvist, J. Cheminformatics, 2020, 12, 1-18, doi:10.1186/s13321-020-00441-8

306. The name tells the story: Two-pore channels (commentary) Paulina Stokłosa, Daniel Probst, Jean-Louis Reymond, Christine Peinelt, Cell Calcium, 2020, 89, 102215, doi:10.1016/j.ceca.2020.102215

305. ‘Ring Breaker’: Neural Network Driven SynthesisPrediction of the Ring System Chemical Space Amol Thakkar, Nidhal Selmi, Jean-Louis Reymond, Ola Engkvist, Esben Bjerrum, J. Med. Chem., 2020, 63(16), 8791-8808, doi:10.1021/acs.jmedchem.9b01919

304. The Generated Databases (GDBs) as a Source of 3D-shaped Building Blocks for Use in Medicinal Chemistry and Drug Discovery Kris Meier, Sven Bühlmann, Josep Arús-Pous, Jean-Louis Reymond, Chimia, 2020, 74(4), 241-246, doi:10.2533/chimia.2020.241

303. Structure and mechanism of the ER-based glucosyltransferase ALG6 Joël S. Bloch, Giorgio Pesciullesi, Jérémy Boilevin, Kamil Nosol, Rossitza N. Irobalieva, Tamis Darbre, Markus Aebi, Anthony A. Kossiakoff, Jean-Louis Reymond & Kaspar P. Locher, Nature, 2020, 579(7799), 443-447, doi:10.1038/s41586-020-2044-z

302. Visualization of very large high-dimensional data sets as minimum spanning trees Daniel Probst, Jean-Louis Reymond, J. Cheminformatics, 2020, 12(1), 1-13, doi:10.1186/s13321-020-0416-x

301. Adaptive and mutational responses to peptide dendrimer antimicrobials in Pseudomonas aeruginosa Fatma Ben Jeddou, Léna Falconnet, Alexandre Luscher, Thissa Siriwardena, Jean-Louis Reymond, Christian van Delden, Thilo Köhler, Antimicrob. Agents Chemother., 2020, 64(4), e02040-19, doi:10.1128/AAC.02040-19

300. ChEMBL-Likeness Score and Database GDBChEMBL Sven Bühlmann, Jean-Louis Reymond, Front. Chem, 2020, 8, 46, doi:10.3389/fchem.2020.00046

299. Populating Chemical Space with Peptides using a Genetic Algorithm Alice Capecchi, Alain Zhang, Jean-Louis Reymond, J. Chem. Inf. Model., 2020, 60(1), 121-132, doi:10.1021/acs.jcim.9b01014

298. Datasets and their influence on the development of computer assisted synthesis planning tools in the pharmaceutical domain Amol Thakkar, Thierry Kogej, Jean-Louis Reymond, Ola Engkvist and Esben Bjerrum, Chem. Sci., 2020, 11, 154-168, doi:10.1039/C9SC04944D


297. Exploring Chemical Space with Machine Learning Josep Arús-Pous, Mahendra Awale, Daniel Probst, and Jean-Louis Reymond, Chimia, 2019, 73(12), 1018-1023, doi:10.2533/chimia.2019.1018

296. Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds Cristina Manatschal, Jonai Pujol-Giménez, Marion Poirier, Jean-Louis Reymond, Matthias A Hediger, Raimund Dutzler, eLife, 2019, 8, e51913, doi:10.7554/eLife.51913

295. Fluorescence Imaging of Bacterial Killing by Antimicrobial Peptide Dendrimer G3KL Bee-Ha Gan, Thissa N. Siriwardena, Sacha Javor, Tamis Darbre, Jean-Louis Reymond, ACS Infect. Dis., 2019, 5(12), 2164-2173, doi:10.1021/acsinfecdis.9b00299

294. Glycocluster Tetrahydroxamic Acids Exhibiting Unprecedented Inhibition of Pseudomonas aeruginosa Biofilms Marwa Taouai, Khouloud Chakroun, Roman Sommer, Gaelle Michaud, David Giacalone, Mohamed Amine Ben Maaouia, Aurélie Vallin-Butruille, David Mathiron, Rym Abidi, Tamis Darbre, Peter J. Cragg, Catherine Mullié, Jean-Louis Reymond, George A. O’Toole, Mohammed Benazza, J. Med. Chem., 2019, 62(17), 7722-7738, doi:10.1021/acs.jmedchem.9b00481

293. X‐Ray Crystal Structure of a Second Generation Peptide Dendrimer in Complex with Pseudomonas aeruginosa Lectin LecB Stéphane Baeriswyl, Sacha Javor, Achim Stocker, Tamis Darbre, Jean-Louis Reymond, Helv. Chim. Acta, 2019, 102(9), e1900178, doi:10.1002/hlca.201900178

292. Stereoselective pH Responsive Peptide Dendrimers for siRNA Transfection Marc Heitz, Sacha Javor, Tamis Darbre, Jean-Louis Reymond, Bioconjugate Chem, 2019, 30(8), 2165-2182, doi:10.1021/acs.bioconjchem.9b00403

291. Photoswitchable Inhibitor of the Calcium Channel TRPV6 Micael R. Cunha, Rajesh Bhardwaj, Sonja Lindinger, Carmen Butorac, Christoph Romanin, Matthias A. Hediger and Jean-Louis Reymond, ACS Med. Chem. Lett., 2019, 10(9), 1341-1345, doi:10.1021/acsmedchemlett.9b00298

290. Randomized SMILES Strings Improve the Quality of Molecular Generative Models Josep Arús-Pous, Simon Johansson, Oleksii Ptykhodko, Esben Jannik Bjerrum, Christian Tyrchan, Jean-Louis Reymond, Hongming Chen, Ola Engkvist, J. Cheminformatics, 2019, 11(1), 1-13, doi:10.1186/s13321-019-0393-0

289. Peptide dendrimers G3KL and TNS18 inhibit Pseudomonas aeruginosa biofilms Xiao Han, Yujie Liu, Yibing Ma, Mengqing Zhang, Zhengjin He, Thissa N. Siriwardena, Haijin Xu, Yanling Bai, Xiuming Zhang, Jean-Louis Reymond, Mingqiang Qiao, Appl Microbiol Biotechnol, 2019, 103(14), 5821-5830

288. Medicinal Chemistry Aware Database GDBMedChem Mahendra Awale, Finton Sirockin, Nikolaus Stiefl, Jean-Louis Reymond, Mol. Inform., 2019, 38(8-9), 1900031, doi:10.1002/minf.201900031

287. Drug Analogs from Fragment-Based Long Short-Term Memory Generative Neural Networks Mahendra Awale, Finton Sirockin, Nikolaus Stiefl, Jean-Louis Reymond, J. Chem. Inf. Model., 2019, 59(4), 1347-1356

286. Mapping the Azolog Space Enables the Optical Control of New Biological Targets Johannes Morstein, Mahendra Awale, Jean-Louis Reymond, and Dirk Trauner, ACS Cent. Sci., 2019, 5(4), 607-618

285. Exploring the GDB-13 Chemical Space Using Deep Generative Models Josep Arús-Pous, Thomas Blaschke, Silas Ulander, Jean-Louis Reymond, Hongming Chen, Ola Engkvist, J. Cheminformatics, 2019, 11(1), 1-14

284. PubChem and ChEMBL Beyond Lipinski Alice Capecchi, Mahendra Awale, Daniel Probst, Jean-Louis Reymond, Mol. Inform., 2019, 38(5), 1900016

283. X-ray Crystal Structures of Short Antimicrobial Peptides as Pseudomonas aeruginosa Lectin B Complexes Stéphane Baeriswyl, Bee-Ha Gan, Thissa N. Siriwardena, Ricardo Visini, Maurane Robadey, Sacha Javor, Achim Stocker, Tamis Darbre , and Jean-Louis Reymond, ACS Chem. Biol., 2019, 14(4), 758-766, doi:10.1021/acschembio.9b00047

282. Antimicrobial Peptide Dendrimer Chimera Thissa Siriwardena, Alexandre Lüscher, Thilo Köhler, Christian van Delden, Sacha Javor, Jean-Louis Reymond, Helvetica Chimica Acta, 2019, 102(4), e1900034

281. Optimizing TRPM4 inhibitors in the MHFP6 chemical space Clémence Delalande, Mahendra Awale, Matthias Rubin, Daniel Probst, Lijo C. Ozhathil, Jürg Gertsch, Hugues Abriel, Jean-Louis Reymond, Eur. J. Med. Chem., 2019, 166, 167-177

280. Web-Based Tools for Polypharmacology Prediction Mahendra Awale, Jean-Louis Reymond, Systems Chemical Biology. Methods Mol Biol, Humana Press, New York, NY, 2019, 255-272.

279. Identifying Lysophosphatidic Acid Acyltransferase β (LPAAT‐β) as the Target of a Nanomolar Angiogenesis Inhibitor from a Phenotypic Screen Using the Polypharmacology Browser PPB2 Marion Poirier, Mahendra Awale, Matthias A. Roelli, Guy T. Giuffredi, Lars Ruddigkeit, Lasse Evensen, Amandine Stooss, Serafina Calarco, James B. Lorens, Roch‐Philippe Charles, Jean‐Louis Reymond, ChemMedChem, 2019, 14(2), 224-236


278. A Probabilistic Molecular Fingerprint for Big Data Settings Daniel Probst, Jean-Louis Reymond, J. Cheminformatics, 2018, 66(10), doi:10.1186/s13321-018-0321-8

277. The Polypharmacology Browser PPB2: Target Prediction Combining Nearest Neighbors with Machine Learning Mahendra Awale, Jean-Louis Reymond, J. Chem. Inf. Model., 2018, doi:10.1021/acs.jcim.8b00524

276. Structure of bacterial oligosaccharyltransferase PglB bound to a reactive LLO and an inhibitory peptide Maja Napiórkowska, Jérémy Boilevin, Tamis Darbre, Jean-Louis Reymond & Kaspar P. Locher, Scientific Reports, 2018, 8(1), 16297

275. Peptide dendrimers as “lead compounds” for the treatment of chronic lung infections by Pseudomonas aeruginosa in cystic fibrosis patients: in vitro and in vivo studies Arianna Pompilio, Cristina Geminiani, Paolo Mantini, Thissa N Siriwardena, Ivan Di Bonaventura, Jean Louis Reymond, Giovanni Di Bonaventura, Infect Drug Resist, 2018, 11, 1767-1782

274. Exploring DrugBank in Virtual Reality Chemical Space Daniel Probst and Jean-Louis Reymond, J. Chem. Inf. Model., 2018, 58(9), 1731-1735

273. Novel peptide-dendrimer/lipid/oligonucleotide ternary complexes for efficient cellular uptake and improved splice-switching activity Osama Saher and Cristina S.J. Rocha and Eman M. Zaghloul and Oscar P.B. Wiklander and Susanna Zamolo and Marc Heitz and Kariem Ezzat and Dhanu Gupta and Jean-Louis Reymond and Rula Zain and Florian Hollfelder and Tamis Darbre and Karin E. Lundin and Samir EL Andaloussi and C.I. Edvard Smith, Eur J Pharm Biopharm., 2018, 132(0939-6411), 29-40

272. Synthesis of Lipid-Linked Oligosaccharides (LLOs) and Their Phosphonate Analogues as Probes To Study Protein Glycosylation Enzymes Jérémy M. Boilevin, Jean-Louis Reymond, Synthesis, 2018, 50(14), 2631-2654

271. Optimizing Antimicrobial Peptide Dendrimers in Chemical Space Thissa Siriwardena, Alice Capecchi, Bee-Ha Gan, Xian Jin, Runze He, Dengwen Wei, Lan Ma, Thilo Köhler, Christian van Delden, Sacha Javor, Jean-Louis Reymond, Angew. Chem. Int. Ed. Engl., 2018, 57(28), 8483-8487

270. Identification of potent and selective small molecule inhibitors of the cation channel TRPM4 Lijo Cherian Ozhathil, Clémence Delalande, Beatrice Bianchi, Gabor Nemeth, Sven Kappel, Urs Thomet, Daniela Ross‐Kaschitza, Céline Simonin, Matthias Rubin, Jürg Gertsch Martin Lochner, Christine Peinelt, Jean‐Louis Reymond, and Hugues Abriel, Br. J. Pharmacol., 2018, 175(12), 2504-2519

269. An Antimicrobial Bicyclic Peptide from Chemical Space Against Multidrug Resistant Gram-Negative Bacteria Ivan Dibonaventura, Stéphane Baeriswyl, Alice Capecchi, Bee-Ha Gan, Xian Jin, Thissa Nuwan Siriwardena, Runze He, Thilo Kohler, Arianna Pompilio, Giovanni Di Bonaventura, Christian van Delden, Sacha Javor and Jean-Louis Reymond, ChemComm, 2018, 54(40), 5130-5133

268. Deep Learning Invades Drug Design and Synthesis (commentary) J58 (9)osep Arús-Pous, Daniel Probst, and Jean-Louis Reymond, Chimia, 2018, 72(1), 70-71

267. Structural basis of the molecular ruler mechanism of a bacterial glycosyltransferase Ana S. Ramírez, Jérémy Boilevin, Ahmad Reza Mehdipour, Gerhard Hummer, Tamis Darbre, Jean-Louis Reymond & Kaspar P. Locher, Nature communications, 2018, 9(1), 445

266. Mapping of the Available Chemical Space versus the Chemical Universe of Lead-Like Compounds Lin A, Horvath D, Afonina V, Marcou G, Reymond JL, Varnek A, ChemMedChem, 2018, 13(6), 540-554

265. SmilesDrawer: parsing and drawing SMILES-encoded molecular structures using client-side JavaScript Daniel Probst and Jean-Louis Reymond, J. Chem. Inf. Model., 2018, 58(1), 1–7

264. Lipidated Peptide Dendrimers Killing Multidrug Resistant Bacteria Thissa N. Siriwardena, Michaela Stach, Runze He, Bee-Ha Gan, Sacha Javor, Marc Heitz, Lan Ma, Xiangjun Cai, Peng Chen, Dengwen Wei, Hongtao Li, Jun Ma, Thilo Koehler, Christian van Delden, Tamis Darbre, and Jean-Louis Reymond, J. Am. Chem. Soc, 2018, 140(1), 423–432


263. FUn: A Framework for Interactive Visualizations of Large, High Dimensional Datasets on the Web Daniel Probst and Jean-Louis Reymond, Bioinformatics, 2017, 34(8), 1433-1435

262. Chemical Space: Big Data Challenge for Molecular Diversity Awale M, Visini R, Probst D, Arús-Pous J, Reymond JL. Chimia, 2017, 71(10), 661-666

261. Molecular basis of lipid-linked oligosaccharide recognition and processing by bacterial oligosaccharyltransferase Maja Napiórkowska, Jérémy Boilevin, Tina Sovdat, Tamis Darbre, Jean-Louis Reymond, Markus Aebi & Kaspar P Locher, Nature Structural and Molecular Biology, 2017, doi:10.1038/nsmb.3491

260. Virtual Exploration of the Ring Systems Chemical Universe Ricardo Visini, Josep Arús-Pous, Mahendra Awale, and Jean-Louis Reymond, J. Chem. Inf. Model., 2017, 57(11), 2707-18

259. Frontiers in Medicinal Chemistry 2017 in Bern, Switzerland Daniel Probst, Marc Heitz, Marion Poirier, Bee Ha Gan, Clémence Delalande, Prof. Dr. Jean-Louis Reymond, ChemMedChem, 2017, 12(19), 1645-1651

258. Medicinal and Biological Chemistry (MBC) Library: An Efficient Source of New Hits Víctor Sebastián-Pérez, Carlos Roca, Mahendra Awale, Jean-Louis Reymond, Ana Martinez, Carmen Gil, and Nuria E. Campillo, J. Chem. Inf. Model., 2017, 57(9), 2143-2151

257. Design, crystal structure and atomic force microscopy study of thioether ligated D,L-cyclic antimicrobial peptides against multidrug resistant Pseudomonas aeruginosa Runze He, Ivan Dibonaventura, Ricardo Visini, Bee-Ha Gan, Yongchun Fu, Daniel Probst,  Alexandre Luscher, Thilo Kohler, Christian van Delden, Achim Stocker, Wenjing Hong, Tamis Darbre and Jean-Louis Reymond, Chem. Sci., 2017, 8(11), 7464-7475

256. Chemical Space Guided Discovery of Antimicrobial Bridged Bicyclic Peptides Against Pseudomonas aeruginosa and its Biofilms Ivan Dibonaventura, Xian Jin, Ricardo Visini, Daniel Probst, Sacha Javor, Bee-Ha Gan, Gaelle Michaud, Antonino Natalello, Silvia Maria Doglia, Thilo Kohler, Christian van Delden, Achim Stocker, Tamis Darbre and Jean-Louis Reymond, Chem. Sci., 2017, 8(10), 6784-98

255. Chemo-enzymatic synthesis of lipid-linked GlcNAc2Man5 oligosaccharides using recombinant Alg1, Alg2 and Alg11 proteins Ana S Ramírez, Jérémy Boilevin, Chia-Wei Lin, Bee Ha Gan, Daniel Janser, Markus Aebi, Tamis Darbre, Jean-Louis Reymond, Kaspar P Locher, Glycobiology, 2017, doi:10.1093/glycob/cwx045

254. Peptide Dendrimer-Lipid Conjugates as DNA and siRNA Transfection Reagents: Role of Charge Distribution Across Generations Marc Heitz, Albert Kwok, Gabriela A. Eggimann, Florian Hollfelder, Tamis Darbre, and Jean-Louis Reymond, Chimia, 2017, 71(4), 220-225

253. Fragment Database FDB-17 Ricardo Visini, Mahendra Awale and Jean-Louis Reymond, J. Chem. Inf. Model., 2017, 57(4), 700–709

252. WebMolCS: a Web-Based Interface for Visualizing Molecules in 3D Chemical Spaces Mahendra Awale, Daniel Probst and Jean-Louis Reymond, J. Chem. Inf. Model., 2017, 57(4), 643–649

251. The polypharmacology browser: a web-based multi-fingerprint target prediction tool using ChEMBL bioactivity data Mahendra Awale, and Jean-Louis Reymond, J. Cheminform., 2017, 9, 11

250. Characterization of the single-subunit oligosaccharyltransferase STT3A from Trypanosoma brucei using synthetic peptides andlipid-linked oligosaccharide analogs
Ana S. Ramírez Jérémy Boilevin Rasomoy Biswas Bee Ha Gan Daniel Janser Markus Aebi Tamis Darbre Jean-Louis Reymond Kaspar P. Locher, Glycobiology, 2017, 27(6), 525-535

249. Improved fluorescence assays to measure the defects associated with F508del-CFTR allow identification of new active compounds Emily Langron, Michela I. Simone, Clémence M.S. Delalande, Jean-Louis Reymond, David L. Selwood, Paola Vergani, T. Br J Pharmacol, 2017. 174(7), 525-539


248. Efficient Transfection of siRNA by Peptide Dendrimer–Lipid Conjugates Kwok, A., Eggimann, G. A., Heitz, M., Reymond, J.-L., Hollfelder, F. and Darbre, T. ChemBioChem, 2016. 17(23), 2223–2229

247. BIGCHEM: Challenges and Opportunities for Big Data Analysis in Chemistry Igor V. Tetko, Ola Engkvist, Uwe Koch, Jean-Louis Reymond, Hongming Chen Analysis in Chemistry. Mol. Inf., 2016, 35(11-12), 615-621

246. Fluorescent Agonists of the α7 Nicotinic Acetylcholine Receptor Derived from 3-Amino-Quinuclidine Justus J. Bürgi, Sonia Bertrand, Fabrice Marger, Daniel Bertrand, Jean-Louis Reymond Helvetica Chimica Acta, 2016, 99(10), 790–804

245. Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening Falco Kilchmann, Maria J. Marcaida, Sachin Kotak, Thomas Schick, Silvan D. Boss, Mahendra Awale, Pierre Gönczy, and Jean-Louis Reymond J. Med. Chem., 2016, 59(15), 7188-7211

244. Web-based 3D-visualization of the DrugBank chemical space Awale M and Reymond JL, J. Cheminform., 2016, 8, 25.

243. Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages. Abdel-Sayed P, Kaeppli A, Siriwardena T, Darbre T, Perron K, Jafari P, Reymond JL, Pioletti DP, Applegate LA, Sci. Rep., 2016, 6.

242. X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair. P. Roethlisberger, A. Istrate, M. J. Marcaida Lopez, R. Visini, A. Stocker, J.-L. Reymond and C. J. Leumann, Chem. Commun., 2016, 52(26), 4749-52.

241. Enumeration of Chemical Fragment Space. Book Chapter in Fragment-based Drug Discovery. J.-L. Reymond, R. Visini, M. Awale. Ed. D. A. Erlanson, W. Jahnke, Wiley-VCH, Weinheim, 2016, pp. 57-75.

240. Overcoming antibiotic resistance in Pseudomonas aeruginosa biofilms using glycopeptide dendrimers. G. Michaud, R. Visini, M. Bergmann, G. Salerno, R. Bosco, E. Gillon, B. Richichi, C. Nativi, A. Imberty, A. Stocker, T. Darbre, JL Reymond, Chem. Sci., 2016, 7, 166-182.

239. Multivalency effects on Pseudomonas aeruginosa biofilm inhibition and dispersal by glycopeptide dendrimers targeting lectin LecA. M Bergmann, G Michaud, R Visini, X Jin, E Gillon, A Stocker, A Imberty, T Darbre, JL Reymond, Org. Biomol. Chem., 2016, 14, 138-148.


238. In Vitro Activity of a Novel Antimicrobial Peptide Dendrimer (G3KL) Against Multidrug-Resistant Acinetobacter baumannii and Pseudomonas aeruginosa. J Pires, T N Siriwardena, M Stach, R Tinguely, S Kasraian, F Luzzaro, S L Leib, T Darbre, JL Reymond, A Endimiani, Antimicrob. Agents Chemother., 2015, 59, 7915-7918.

237. PDB-Explorer: a Web-Based Interactive Map of the Protein Data Bank in Shape Space. X Jin, M Awale, M Zasso, D Kostro, L Patiny, JL Reymond, BMC Bioinform., 2015, 16, 339.

236. Optimization of TRPV6 Calcium Channel Inhibitors Using a 3D Ligand-Based Virtual Screening Method. C Simonin, M Awale, Michael Brand, R van Deursen, J Schwartz, M Fine, G Kovacs, P Häfliger, G Gyimesi, A Sithampari, RP Charles, MA Hediger, JL Reymond, Angew. Chem., Int. Ed. Engl., 2015, 54, 14748-14752.

235. Structural Insight into Multivalent Galactoside Binding to Pseudomonas aeruginosa Lectin LecA. Visini R, Jin X, Bergmann M, Michaud G, Pertici F, Fu O, Pukin A, Branson TR, Thies-Weesie DM, Kemmink J, Gillon E, Imberty A, Stocker A, Darbre T, Pieters RJ, Reymond JL, ACS Chem. Biol., 2015, 10, 2455-2462.

234. Structure and mechanism of an active lipid-linked oligosaccharide flippase. Perez C, Gerber S, Boilevin J, Bucher M, Darbre T, Aebi M, Reymond JL, Locher KP, Nature., 2015, 524, 433-438.

233. Similarity Mapplet: Interactive Visualization of the Directory of Useful Decoys and ChEMBL in High Dimensional Chemical Spaces. Awale M, Reymond JL, J. Chem. Inf. Model., 2015, 55, 1509-1516.

232. Bridged bicyclic peptides as potential drug scaffolds: synthesis, structure, protein binding and stability. Bartoloni M, Jin X, Marcaida M, Banha J, Dibonaventura I, Bongoni S, Bartho K, Gräbner O, Sefkow M, Darbre T, Reymond JL, Chem. Sci., 2015, 6, 5473-5490.

231. Trypanosoma brucei Bloodstream Forms Depend upon Uptake of myo-Inositol for Golgi Complex Phosphatidylinositol Synthesis and Normal Cell Growth. Gonzalez-Salgado, A.; Steinmann, M.; Major, L. L.; Sigel, E.; Reymond, J. L.; Smith, T. K.; Butikofer, P., Eukaryot. Cell, 2015, 14, 616-624.

230. Discovery and characterization of a novel non-competitive inhibitor of the divalent metal transporter DMT1/SLC11A2. Montalbetti, N.; Simonin, A.; Simonin, C.; Awale, M.; Reymond, J. L.; Hediger, M. A., Biochem. Pharmacol., 2015, 96, 216-224.

229. Cytotoxic peptide conjugates of dinuclear arene ruthenium trithiolato complexes. Giannini F, Bartoloni M, Paul LE, Süss-Fink G, Reymond JL, Furrer J, Med. Chem. Commun., 2015, 6, 347-350.

228. The chemical space project. Reymond JL, Acc. Chem. Res., 2015, 48, 722-730. This work was featured in:

227. Stereoselective virtual screening of the ZINC database using atom pair 3D-fingerprints. Awale M, Jin X, Reymond JL, J. Cheminform., 2015, 7, 3.


226. The Chemical Space of Flavours. Book Chapter in Foodinformatics, Applications of Chemical Information to Food Chemistry. L. Ruddigkeit, J.-L. Reymond, Ed. K. Martinez-Mayorga, J. L. Medina-Franco, Springer, Heidelberg, 2014, pp. 83-96.

225. Combining Topology and Sequence Design for the Discovery of Potent Antimicrobial Peptide Dendrimers against Multidrug-Resistant Pseudomonas aeruginosa. Stach M, Siriwardena TN, Köhler T, van Delden C, Darbre T, Reymond JL, Angew Chem Int Ed Engl. 2014, 53, 12827-12831.

224. Substrate specificity of cytoplasmic N-glycosyltransferase. Naegeli A, Michaud G, Schubert M, Lin CW, Lizak C, Darbre T, Reymond JL, Aebi M, J Biol Chem. 2014, 289, 24521-24532.

223. Atom Pair 2D-Fingerprints Perceive 3D-Molecular Shape and Pharmacophores for Very Fast Virtual Screening of ZINC and GDB-17. M. Awale, J.-L. Reymond, J. Chem. Inf. Model. 2014, 54, 1892-1907.

222. Expanding the fragrance chemical space for virtual screening. L. Ruddigkeit, M. Awale, J.-L. Reymond, J. Cheminform. 2014, 6, 27.

221. Designed Cell Penetration Peptide Dendrimers Efficiently Internalize Cargo Into Cells. G. A. Eggimann, E. Blattes, S. Buschor, R. Biswas, S. M. Kammer, T. Darbre, J.-L. Reymond, Chem. Commun. 2014, 50, 7254-7257.

220. Discovery of Potent Positive Allosteric Modulators of the α3β2 Nicotinic Acetylcholine Receptor by a Chemical Space Walk in ChEMBL. J. Bürgi, M. Awale, S. Boss, T. Schaer, F. Marger, J. Viveros-Paredes, S. Bertrand, J. Gertsch, D. Bertrand, J.-L. Reymond, ACS Chem. Neurosci. 2014, 5, 346-359.

219. A multi-fingerprint browser for the ZINC database. M. Awale, J.-L. Reymond, Nucleic Acids Res. 2014, 42, 234-239.

218. OMA & OPA - A Software Tool for Mass Spectrometric Sequencing of Nucleic Acids. Y. Hari, S. R. Stücki, A. Nyakas, L. Blum, J.-L. Reymond, S. Schürch, Chimia, 2014, 68, 86.

217. Stereoselective synthesis and structure determination of bicyclo[3.3.2]decapeptide. M. Bartoloni, S. Waltersperger, M. Bumann, A. Stocker, T. Darbre and J.-L. Reymond, Arkivoc, 2014, iii, 113-123.

216. A Tribute to Pierre Vogel. R. Neier and J.-L. Reymond, Arkivoc, 2014, iii, 1-5 (editorial).

215. [Considerations on the Drug-Like Chemical Space.](Considerations on the Drug-Like Chemical Space) Book Chapter in Computational Chemogenomics, J.-L. Reymond, L. Ruddigkeit, M. Awale, Ed. E. Jacoby, Pan Standford Publishing, Singapore, 2014, pp. 39-64.

214. A "Social" Network of Isomers based on Bond Count Distance: Algorithms. T. Kouri, M. Awale, J. Slyby, J.-L. Reymond, D. Mehta, J. Chem. Inf. Model. 2014, 54, 57-68.

213. A catalytically essential motif in the external loop 5 of the bacterial oligosaccharyltransferase PglB. C. Lizak, S. Gerber, D. Zinne , G. Michaud, M. Schubert, F. Chen, M. Bucher, T. Darbre, R. Zenobi, J.-L. Reymond , K. P. Locher, J. Biol. Chem. 2014, 289, 735-746.


212. Expanding the Topological Space of Bioactive Peptides. J.-L. Reymond, T. Darbre, Chimia 2013, 67, 864-867.

211. Unexpected reactivity and mechanism of carboxamide activation in bacterial N-linked protein glycosylation. C. Lizak, S. Gerber, G. Michaud, M. Schubert, Y. Y. Fan, M. Bucher, T. Darbre, M. Aebi, J.-L. Reymond, K. P. Locher, Nat. Commun. 2013, 4, 2627.

210. Structure-Based Optimization of the Terminal Tripeptide in Glycopeptide Dendrimer Inhibitors of Pseudomonas aeruginosa Biofilms Targeting LecA. R. U. Kadam, M. Bergmann, D. Garg, G. Gabrieli, A. Stocker, T. Darbre, J.-L. Reymond, Chem. Eur. J. 2013, 18, 17054-17063.

209. Electrostatics and flexibility drive membrane recognition and early penetration by the antimicrobial peptide dendrimer bH1. H. K. Ravi, M. Stach, T. A. Soares, T. Darbre, J.-L. Reymond, M. Cascella, Chem. Commun. 2013, 49, 8821-8823.

208. CH-π "T-Shape" Interaction with Histidine Explains Binding of Aromatic Galactosides to Pseudomonas aeruginosa lectin LecA. R. U. Kadam, D. Garg J. Schwartz, R. Visini, M. Sattler, A. Stocker, T. Darbre, J.-L. Reymond, ACS Chem. Biol. 2013, 8, 1925-1930.

207. Convergent synthesis and cellular uptake of multivalent cell penetrating peptides derived from Tat, Antp, pVEC, TP10 and SAP. G. A. Eggimann, S. Buschor, T. Darbre and J.-L. Reymond, Org. Biomol. Chem. 2013, 11, 6717-6733.

206. The SMIfp (SMILES fingerprint) Chemical Space for Virtual Screening and Visualization of Large Databases of Organic Molecules. J. Schwartz J, M. Awale and J.-L. Reymond, J. Chem. Inf. Model. 2013, 53, 1979-1989.

205. Peptide Dendrimer/Lipid Hybrid Systems are Efficient DNA Transfection Reagents: Structure-Activity Relationships Highlight the Role of Charge Distribution Across Dendrimer Generations. A. Kwok, Albert, G. Eggimann, J.-L. Reymond, T. Darbre, F. Hollfelder, ACS Nano. 2013, 7, 4668-4682.

204. Fluorescence-Based Assay for the Optimization of the Activity of Artificial Transfer Hydrogenase within a Biocompatible Compartment. T. Heinisch, K. Langowska, P. Tanner, J.-L. Reymond, W. Meier, C. Palivan, T. R. Ward, ChemCatChem. 2013, 5, 720-723.

203. Mechanism of bacterial oligosaccharyltransferase: in vitro quantification of sequon binding and catalysis. S. Gerber, C. Lizak, G. Michaud, M. Bucher, T. Darbre, M. Aebi, J.-L. Reymond, K. P. Locher, J. Biol. Chem. 2013, 288, 8849-8861.

202. Glycopeptide dendrimers as Pseudomonas aeruginosa biofilm inhibitors. J.-L. Reymond, M. Bergmann, T. Darbre, Chem. Soc. Rev. 2013, 42, 4814-4822.

201. The MQN-Mapplet: Visualization of Chemical Space with Interactive Maps of DrugBank, ChEMBL, PubChem, GDB-11 and GDB-13. M. Awale, R. van Deursen, J.-L. Reymond, J. Chem. Inf. Model. 2013, 53, 509-518.

200. Visualization and Virtual Screening of the Chemical Universe Database GDB-17. L. Ruddigkeit, L. C. Blum, J.-L. Reymond, J. Chem. Inf. Model. 2013, 53, 56-65.

199. OMA and OPA-Software-Supported Mass Spectra Analysis of Native and Modified Nucleic Acids. Nyakas, L. C. Blum, S. R. Stucki, J.-L. Reymond, S. Schurch, J. Am. Soc. Mass. Spectrom. 2013, 24, 249-256.

198. Multivalent glycoconjugates as anti-pathogenic agents. A. Bernardi, J. Jimenez-Barbero, A. Casnati, C. De Castro, T. Darbre, F. Fieschi, J. Finne, H. Funken, K. E. Jaeger, M. Lahmann, T. K. Lindhorst, M. Marradi, P. Messner, A. Molinaro, P. V. Murphy, C. Nativi, S. Oscarson, S. Penades, F. Peri, R. J. Pieters, O. Renaudet, J.-L. Reymond, B. Richichi, J. Rojo, F. Sansone, C. Schaffer, W. B. Turnbull, T. Velasco-Torrijos, S. Vidal, S. Vincent, T. Wennekes, H. Zuilhof, A. Imberty, Chem. Soc. Rev. 2013, 42, 4709-4727.

197. pH-tuned metal coordination and peroxidase activity of a peptide dendrimer enzyme model with a Fe(ii)bipyridine at its core. P. Geotti-Bianchini, T. Darbre, J.-L. Reymond, Org. Biomol. Chem., 2013, 11, 344-352.


196. Screening Methods for Enzymes. J.-L. Reymond, Book Chapter in Comprehensive Chirality, Ed. E. M. Carreira, H. Yamamoto, Eds. Elsevier, Amsterdam, 2012, pp. 6-20.

195. Enumeration of 166 billion organic small molecules in the chemical universe database GDB-17. L. Ruddigkeit, R. van Deursen, L. C. Blum and J.-L. Reymond, J. Chem. Inf. Model., 2012, 52, 2864-2875.

194. Synthesis and Nicotinic Receptor Activity of Chemical Space Analogs of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711). L. Bréthous, N. Garcia-Delgado, J. Schwartz, S. Bertrand, D. Bertrand and J.-L. Reymond, J. Med. Chem., 2012, 55, 4605-4618.

193. Exploring chemical space for drug discovery using the chemical universe database. J.-L. Reymond and M. Awale, ACS Chem. Neurosci., 2012, 3, 649-657.

192. The enumeration of chemical space. J.-L. Reymond, L. Ruddigkeit, L. Blum, R. van Deursen, WIREs Comput. Mol. Sci. 2012, 2, 717-733.

191. Cluster analysis of the DrugBank chemical space using molecular quantum numbers. M. Awale and J.-L. Reymond, Bioorg. Med. Chem. 2012, 18, 5372-5378.

190. Peptide and glycopeptide dendrimer apple trees as enzyme models and for biomedical applications. T. Darbre and J.-L. Reymond, Org. Biomol. Chem. 2012, 10, 1483-1492.

189. Membrane disrupting antimicrobial peptide dendrimers with multiple amino termini. M. Stach, N. Maillard, R. U. Kadam, D. Kalbermatter, M. Meury, M. G. P. Page, D. Fotiadis, T. Darbre and J.-L. Reymond, MedChemComm. 2012, 3, 86-89.


188. Exploring the chemical space of known and unknown organic small molecules at L. C. Blum, R. van Deursen, and J.-L. Reymond, Chimia 2011, 65, 863-867.

187. Discovery of a7-Nicotinic Receptor Ligands by Virtual Screening of the Chemical Universe Database GDB-13. L. C. Blum, R. van Deursen, S. Bertrand, M. Mayer, J. J. Bürgi, D. Bertrand, and J.-L. Reymond, J. Chem. Inf. Model. 2011, 51 3105-3112.

186. Expanding the accessible chemical space by solid phase synthesis of bicyclic homodetic peptides. M. Bartoloni, R. U. Kadam, J. Schwartz, J. Furrer, T. Darbre, J.-L. Reymond, Chem. Commun. 2011, 47, 12634-12636.

185. Combinatorial Libraries of Dendritic Glycoclusters.Book Chapter in Synthesis and Biological Applications of Glycoconjugates. J.-L. Reymond, T. Darbre,. Ed. O. Renaudet and N. Spinelli, Bentham e-books 2011, pp. 116-128.

184. Peptide Dendrimers as Artificial Proteins. Book chapter in Designing Dendrimers, T. Darbre, J.-L. Reymond, Ed. S. Campagna, P. Ceroni, F Puntoriero, JohnWiley&Sons 2011, pp. 505-528.

183. A Glycopeptide dendrimer inhibitor of the Galactose Specific Lectin LecA and of Pseudomonas aeruginosa Biofilms. R. U. Kadam, M. Bergmann, M. Hurley, D. Garg, M. Cacciarini, M. A. Swiderska, C. Nativi, M. Sattler, A. R. Smyth, P. Williams, M. Cámara, A. Stocker, T. Darbre, J.-L. Reymond, Angew. Chem. Int. Ed. 2011, 50, 10631-10635.

182. Peptide dendrimer enzyme models for ester hydrolysis and aldolization prepared by convergent thioether ligation. N. A. Uhlich, T. Darbre, J.-L. Reymond, Org. Biomol. Chem. 2011, 9, 7071-7084.

181. What we have learned from crystal structures of proteins to receptor function. J.-L. Reymond, R. van Deursen, D. Bertrand, Biochem. Pharmacol. 2011, 82, 1521-1527.

180. Visualisation and subsets of the chemical universe database GDB-13 for virtual screening. L. C. Blum, R. van Deursen, J.-L. Reymond, J. Comput. Aided Mol. Des. 2011, 25, 637-647.

179. Visualisation of the chemical space of fragments, lead-like and drug-like molecules in PubChem. R. van Deursen, L. C. Blum, J.-L. Reymond, J. Comput. Aided Mol. Des. 2011, 25, 649-662.

178. Structural and functional analyses reveal that Staphylococcus aureus antibiotic resistance factor HMRA is a zinc-dependent endopeptidase. T. O. Botelho, T. Guevara, A. Marrero, P. Arêde, V. S. Fluxa J.-L. Reymond, D. C. Oliveira, F. X. Gomis-Rüth, J. Biol. Chem. 2011, 286, 25697-25709.

177. Synthesis of glycopeptide dendrimers, dimerization and affinity for Concanavalin. A. R. Euzen, J.-L. Reymond, Bioorg. Med. Chem. 2011, 19, 2879-2887.

176. Combinatorial Discovery of Peptide Dendrimer Enzyme Models Hydrolyzing Isobutyryl Fluorescein. N. Maillard, R. Biswas, T. Darbre, J.-L. Reymond, ACS Comb. Sci. 2011, 13, 310-320.

175. Inhibition of Pseudomonas aeruginosa biofilms with a glycopeptide dendrimer containing D-amino acids. E. M. V. Johansson, R. U. Kadam, G. Rispoli, S. A. Crusz, K. M. Bartels, S. P. Diggle, M. Cámara, P.Williams, K. E. Jaeger, T. Darbre, J.-L. Reymond, Med. Chem. Commun. 2011, 2, 418-420.

174. Five-Substrate Cocktail as a Sensor Array for Measuring Enzyme Activity Fingerprints of Lipases and Esterases. N. Maillard, P. Babiak, S. Syed, R.Biswas, L. Mandrich, G. Manco, J.-L. Reymond, Anal. Chem. 2011, 83, 1437-1442.

173. Bead Diffusion Assay for Discovering Antimicrobial Cyclic Peptides. V. S. Fluxa, N. Maillard, M. G. P. Page , J.-L. Reymond, Chem. Commun. 2011, 47 1434-1436.

172. Glycopeptide dendrimers: tuning carbohydrate-lectin interactions with amino acids. R. Euzen, J.-L. Reymond, Mol. Biosys. 2011, 7, 411-421.


171. A Searchable Map of Pubchem. R. van Deursen, L. C. Blum, J.-L. Reymond, J. Chem. Inf. Model. 2010, 50 1924-1934.

170. Comparing dendritic with linear esterase peptides by screening SPOT arrays for catalysis. R. Biswas, N. Maillard, J. Kofoed, J.-L. Reymond, Chem. Commun. 2010 , 8746-8748.

169. Identification of Selective Norbornane-Type Aspartate Analogue Inhibitors of the Glutamate Transporter 1 (GLT-1) from the Chemical Universe Generated Database (GDB). E. Luethi, K. T. Nguyen, M. Bürzle, L.C. Blum, Y. Suzuki, M. Hediger, J.-L. Reymond J. Med. Chem. 2010, 53, 7236-7250.

168. Glycopeptide dendrimer colchicine conjugates targeting cancer cells. E. M.V. Johansson, J. Dubois, T. Darbre, J,-L. Reymond, Bioorg. Med. Chem. 2010, 18, 6589-6597.

167. Exploring a7-Nicotinic Receptor Ligand Diversity by Scaffold Enumeration from the Chemical Universe Database GDB. N. Garcia-Delgado, S. Bertrand, K. T. Nguyen, R. van Deursen, D.Bertrand, J.-L. Reymond, ACS Med. Chem. Lett. 2010, 1, 422-426.

166. Chemical Space as a source for new drugs. J.-L. Reymond, R. van Deursen, L. C. Blum, Lars Ruddigkeit, Med. Chem. Commun. 2010, 1, 30-38.

165. Selected papers from the Biotrans 2009 Conference (Editorial). J.-L. Reymond, J. Mol. Cat. B: Enzymatic 2010, 65, 1-2.

164. Future turnovers in enzyme catalysis (Editorial). J.-L. Reymond, R. A. Sheldon, Curr. Opin. Chem. Biol. 2010, 14, 113-4.

163. Structure and Binding of Peptide-Dendrimer Ligands to Vitamin B12. N. A. Uhlich, A. Natalello, R. U. Kadam, S. M. Doglia, J.-L. Reymond, T. Darbre, Chembiochem 2010, 11, 358-65.


162. A dendritic signal amplifier (commentary). M. Swiderska, J.-L. Reymond, Nature Chemistry 2009, 1, 527-528.

161. Classification of Organic Molecules by Molecular Quantum Numbers. K. T. Nguyen, L. C. Blum, R. van Deursen, J.-L. Reymond, ChemMedChem 2009, 4, 1803-1805.

160. Remote Control of Bipyridine-Metal Coordination within a Peptide Dendrimer. N. A. Uhlich, P. Sommer, C. Bühr, S. Schürch, J.-L. Reymond, T. Darbre, Chem. Commun. 2009, 6237-6239.

159. Structure-Activity Relationship Studies in Single-Site Esterase Peptide Dendrimers. Sacha Javor, J.-L. Reymond, Isr. J. Chem. 2009, 49, 129-136.

158. 970 Million Drug-like Small Molecules for Virtual Screening in the Chemical Universe Database GDB-13. L. C. Blum, J.-L. Reymond, J. Am. Chem. Soc. 2009, 131, 8732-8733.

157. Proteolysis of Peptide Dendrimers. P. Sommer , V. S. Fluxa, T. Darbre, J.-L. Reymond, Chembiochem 2009, 10, 1527-1536.

156. Phenolic oxime oligomers inhibit Alzheimer's amyloid fibril formation and disaggregate fibrils in vitro. G. T. Dolphin, O. Renaudet, M. Ouberai, P. Dumy, J. Garcia, J.-L. Reymond, Chembiochem 2009, 10, 1325-1329.

155. Identification of Catalytic Peptide Dendrimers by "Off-Bead" in Silica High-Throughput Screening of Combinatorial Libraries. N. Maillard, T. Darbre, J.-L. Reymond, J. Comb. Chem. 2009, 11, 667-675.

154. 3-(Aminomethyl)piperazine-2,5-dione as a novel NMDA glycine site inhibitor from the chemical universe database GDB. K. T. Nguyen, E. Luethi, S. Syed, S. Urwyler, S. Bertrand, D. Bertrand, J.-L. Reymond, Bioorg. Med. Chem. Lett. 2009, 19, 3832-2835.

153. [Molecular dynamics and docking studies of single site esterase peptide dendrimers.]
( S. Javor, J.-L. Reymond, J. Org. Chem. 2009, 74, 3665-3674.

152. Exploration of Chemical Space for Drug Discovery by Database Generation. J.-L. Reymond, K. T. Nguyen, Chemistry Today 2009, 27, no. 2, pp 37-40.

151. Fluorescence Assays for Biotransformations. J.-L. Reymond. Book chapter in Modern Biocatalysis, Ed. W.-D. Fessner and T. Anthonsen, Wiley-VCH, Weinheim 2009, pp. 1-16.

150. Glycopeptide dendrimers with high affinity for the fucose binding lectin PA-IIL from Pseudomonas aeruginosa. E. Kolomiets, M. A. Swiderska, R. U. Kadam, E. M. V. Johansson, K.-E. Jaeger, Tamis Darbre, J.-L. Reymond, ChemMedChem 2009, 4, 562-569.

149. Combinatorial Libraries of Peptide Dendrimers: Design, Synthesis, On-Bead High-Throughput Screening, Bead Decoding and Characterization. N. Maillard, A. Clouet, T. Darbre, J.-L. Reymond, Nature Protoc. 2009, 4, 132-142.

148. Enzyme Assays. J.-L. Reymond, V. S. Fluxa N. Maillard, Chem. Commun. 2009, 34-46.

147. On-bead cyclization in a combinatorial library of 15,625 octapeptides. V. S. Fluxa, J.-L. Reymond, Bioorg. Med. Chem. 2009, 17, 1018-1025.


146. α-Helix Stabilization within a Peptide Dendrimer. S. Javor, A. Natalello, S.M. Doglia, J.-L. Reymond, J. Am. Chem. Soc. 2008, 130, 17248-17249.

145. Inhibition and Dispersion of Pseudomonas aeruginosa Biofilms by Glycopeptide Dendrimers Targeting the Fucose-Specific Lectin LecB. E. M. V. Johansson , S. A. Crusz, E. Kolomiets, L. Buts, R. U. Kadam, M. Cacciarini, K.-M. Bartels, S. P. Diggle, M. Cámara, P. Williams, R. Loris, C. Nativi, F. Rosenau, K.-E. Jaeger, T. Darbre, J.-L. Reymond, Chem. Biol. 2008, 15, 1249-1257.

144. Colorimetric and Fluorescence-Based Screening. Book chapter in Protein Engineering Handbook, Ed. S. Lutz, U.T. Bornscheuner, Wiley-VCH, Weinheim 2008, pp. 669-711.

143. A cyclodecapeptide ligand to vitamin B12. V. Duléry, N. A. Uhlich, N. Maillard, V. S. Fluxa J. Garcia, P. Dumy, O. Renaudet, J.-L. Reymond, T. Darbre, Org. Biomol. Chem. 2008, 6, 4134-4141.

142. Glycopeptide dendrimers for biomedical applications. T. Darbre, J.-L. Reymond, Curr. Top. Med. Chem 2008, 8, 1286-1293.

141. Discovery of NMDA Glycine Site Inhibitors from the Chemical Universe Database GDB. K. T. Nguyen, S. Syed, S. Urwyler, S. Bertrand, D. Bertrand, J.-L. Reymond, ChemMedChem 2008, 3, 1520-1524.

140. Enzyme assay and activity fingerprinting of hydrolases with the red-chromogenic adrenaline test. V. S. Fluxa D. Wahler, J.-L. Reymond, Nature Protoc. 2008, 3, 1270-1277.

139. The Search for New Enzymes. J.-L. Reymond, W. Streit, Book Chapter in Organic Synthesis with Enzymes , Ed. V. Gotor, I. Alfonso and E. Garcia-Urdiales, Wiley-VCH, Weinheim, 2008, 65-86.

138. A Peptide Dendrimer Model for Vitamin B(12) Transport Proteins. P. Sommer, N. Uhlich, J.-L. Reymond, T. Darbre, Chembiochem 2008, 9, 689-693.

137. Substrate Arrays for Fluorescence-Based Enzyme Fingerprinting and High-Throughput Screening. J.-L. Reymond, Ann. N. Y. Acad. Sci. 2008, 1130, 12-20.


136. Activity of ulilysin, an archaeal PAPP-A-related gelatinase and IGFBP protease. C. Tallant, R. Garcia-Castellanos, A. Marrero, F. Canals, Y. Yang, J.-L. Reymond, M. Sola, U. Baumann, F. X. Gomis-Ruth.Biol. Chem. 2007, 388, 1243-1253.

135. Identification of protease substrates by combinatorial profiling on tentagel beads. J. Kofoed and J.-L. Reymond. Chem. Commun. 2007, 48, 4453-4455.

134. A General Method for Designing Combinatorial Peptide Libraries Decodable by Amino Acid Analysis. J. Kofoed, J.-L. Reymond, J. Comb. Chem. 2007, 9, 1046-1052.

133. A Peptide Dendrimer Enzyme Model with a Single Catalytic Site at the Core. S. Javor, E. Delort, T. Darbre, J.-L. Reymond, J. Am. Chem. Soc. 2007, 129, 13238-13246.

132. STM-Visualization of Thiol-Containing Peptide Dendrimers on Au(111). E. Delort, E. Szöcs, R. Widmer, H. Siegenthaler, J.-L. Reymond. Macromol. Bioscience 2007, 7, 1024-1031.

131. A Peptide Dendrimer Approach to Artificial Enzymes. T. Darbre, J.-L. Reymond Chemistry Today 2007, 25, 25-27.

130. Combinatorial Variation of Branching Length and Multivalency in a Large (390,625 Member) Glycopeptide Dendrimer Library: Ligands for Fucose-specific Lectins. E. M. V. Johansson, E. Kolomiets, F. Rosenau, K.-E. Jaeger, T. Darbre, J.-L. Reymond, New J. Chem. 2007, 31, 1291-1299.

129. Neoglycopeptide Dendrimer Libraries as a Source of Lectin Binding Ligands. E. Kolomiets, E. M. V. Johansson, O. Renaudet, T. Darbre, J.-L. Reymond, Org. Lett. 2007, 9, 1465-1468.

128. Chemical Space Travel. R. van Deursen, J.-L. Reymond, ChemMedChem 2007, 2, 636-640.

127. Virtual exploration of the chemical universe up to 11 atoms of C, N, O, F: assembly of 26.4 million structures (110.9 million stereoisomers) and analysis for new ring systems, stereochemistry, physico-chemical properties, compound classes and drug discovery. T. Fink, J.-L. Reymond, J. Chem. Inf. Model. 2007, 47, 342-353.

126. Fluorogenic Substrates for Lipases, Esterases and Acylases Using a TIM-Mechanism for Signal Release. R. Sicart, M.-P. Collin, J.-L. Reymond, Biotechnol. J. 2007, 2, 221-231.

125. Screening Systems. J.-L. Reymond, P. Babiak, Adv. Biochem. Eng. Biotechnol.2007, 105, 31-58.


124. Peptide Dendrimers as Artificial Enzymes, Receptors, and Drug-Delivery Agents. T. Darbre, J.-L.  Reymond, Acc. Chem. Res. 2006, 39, 925-934.

123. Artificial aldolases from peptide dendrimer combinatorial libraries. J. Kofoed, T. Darbre, J.-L. Reymond, Org. Biomol. Chem. 2006, 3268-3281.

122. A red-fluorescent substrate microarray for lipase fingerprinting. J. Grognux,  J.-L. Reymond, Mol. Biosys. 2006, 2, 492-498.

121. Synthesis and Activity of Histidine Containing Catalytic Peptide Dendrimers. E. Delort, N.-Q. Nguyen-Trung, T. Darbre and J.-L. Reymond, J. Org. Chem. 2006, 71, 4468-4480.

120. Isolation and biochemical characterization of two novel metagenome-derived esterases. C. Elend, C. Schmeisser, C. Leggewie, P. Babiak, J. D. Carballeira, H. L. Steele, J.-L. Reymond, K.-E. Jaeger, W. R. Streit, Appl. Environ. Microbiol. 2006, 72, 3637-45.

119. Low background FRET- substrates for lipases and esterases suitable for high-throughput screening under basic (pH 11) conditions. Y. Yang, P. Babiak, J.-L. Reymond, Org. Biomol. Chem. 2006, 4, 1746-1754.

118. Dual Mechanism of Zinc-Proline Catalyzed Aldol Reactions in Water. J. Kofoed, T. Darbre, J.-L. Reymond, Chem. Commun. 2006, 1482-1484.

117. New Monofunctionalized Fluorescein Derivatives for the Efficient High-Throughput Screening of Lipases and Esterases in Aqueous Media. Y. Yang, P. Babiak, J.-L. Reymond, Helv. Chim. Acta 2006, 89, 404-415.

116. Fingerprinting Methods for Hydrolases. Book Chapter in Enzyme Assays, Ed. J.-L. Reymond, Wiley-VCH, Weinheim 2006, pp. 271-302.

115. Combinatorial Synthesis, Selection and Properties of Esterase Peptide Dendrimers. A. Clouet, T. Darbre, J.-L. Reymond, Biopolymers 2006, 84,114-123.


114. [Screening Methods for Catalytic Antibodies. Book chapter in Catalytic Antibodies, Ed.](Screening Methods for Catalytic Antibodies. Book chapter in Catalytic Antibodies) E. Keinan, Wiley-VCH, Weinheim,2005,pp. 217-242.

113. Dendrimers as artificial enzymes. J. Kofoed, J.-L. Reymond,Curr. Opin. Chem. Biol. 2005, 9, 656-664.

112. A fluorescence-based assay for Baeyer-Villiger monooxygenases, hydroxylases and lactonases. R. Sicard, L. S. Chen, A. J. Marsaioli, J.-L. Reymond, Adv. Synth. Catal. 2005,347, 1041-1050 .

111. Multienzyme Profiling of Thermophilic Microorganisms with a Substrate Cocktail Assay. R. Sicard, J.-P. Goddard, M. Mazel, C. Audiffrin, L. Fourage, G. Ravot, D. Wahler, F. Lefèvre, J.-L. Reymond, Adv. Synth. Catal. 2005, 347, 987-996 .

110. Prebiotic carbohydrate synthesis: zinc proline catalyzes direct aqueous aldol reactions of α-hydroxy aldehydes and ketones. J. Kofoed, J.-L. Reymond, T. Darbre, Org. Biomol. Chem. 2005, 3, 1850-1855 .

109. Protease Profiling Using a Fluorescent Domino Peptide Cocktail. Y. Yongzheng, J.-L. Reymond, Mol. Biosys. 2005, 1, 57-63 .

108. Synthetic diversity and catalytic mechanism of peptide dendrimers. E. Delort, T. Darbre, J.-L. Reymond, Chimia 2005, 59, 77-80.

107. Inhibition of Mitosis by Glycopeptide Dendrimer Conjugates of Colchicine. D. Lagnoux, T. Darbre, M. L. Schmitz, J.-L. Reymond, Chem. Eur. J. 2005, 11, 3941-3950.

106. Virtual Exploration of the Small Molecule Chemical Universe below 160 Daltons. T. Fink, H. Bruggesser, J.-L. Reymond, Angew. Chem. Int. Ed. 2005, 44, 1504-1508.

105. Mechanistic study of proton transfer and hysteresis in catalytic antibody 16E7 by site-directed mutagenesis and homology modelling. L. Zheng, R. Manetsch, W.-D. Woggon, U. Baumann, J.-L. Reymond, Bioorg. Med. Chem. 2005, 13, 1021-1029.

104. A High-Throughput, Low Volume Enzyme Assay on Solid Support. P. Babiak, J.-L. Reymond, Anal. Chem. 2005, 77, 373-377.


103. Studies on whole cell fluorescence-based screening for epoxide hydrolases and Baeyer-Villiger monooxygenases. B. Bicalho, L. S. Chen, J. Grognux, J.-L. Reymond, A. J. Marsaioli, J. Braz. Chem. Soc. 2004, 15, 911-916.

102. Spectrophotometric Enzyme Assays for High-throughput Screening. J.-L. Reymond, Food Technol. Biotechnol. 2004, 42, 265-269.

101. A Strong Positive Dendritic Effect in a Peptide Dendrimer-Catalyzed Ester Hydrolysis Reaction. E. Delort, T. Darbre, J.-L. Reymond, J. Am. Chem. Soc. 2004, 126, 15642-15643.

100. Outrunning the Bear. J.-L. Reymond, Angew. Chem. Int. Ed. 2004, 43, 5577-5579.

99. New C(4)-Functionalized Colchicine Derivatives by a Versatile Multicomponent Electrophilic Aromatic Substitution. N. Bensel, D. Lagnoux, V. Niggli, M. Wartmann, J.-L. Reymond, Helv. Chim. Acta 2004, 87, 2266-2272.

98. Esterolytic Peptide Dendrimers with a Hydrophobic Core and Catalytic Residues at the Surface. A. Clouet, T. Darbre, J.-L. Reymond, Adv. Synth. Catal. 2004, 346, 1195-1204.

97. Universal chromogenic substrates for lipases and esterases. J. Grognux, D. Wahler, E. Nyfeler, J.-L. Reymond, Tetrahedron Asym. 2004, 15, 2981-2989.

96. An Efficient One-Step Site-Directed and Site-Saturation Mutagenesis Protocol. L. Zheng, U. Baumann, J.-L. Reymond, Nucleic Acids Research Methods Online 2004, 32, e115.

95. Enzyme Fingerprinting with Substrate Cocktails. J.-P. Goddard, J.-L. Reymond, J. Am. Chem. Soc. 2004, 126, 11116-11117.

94. A Combinatorial Approach to Catalytic Peptide Dendrimers. A. Clouet, T. Darbre, J.-L. Reymond, Angew. Chem. Int. Ed. 2004, 43, 4612-4615.

93. Expression Improvement and Mechanistic Study of the Retro-Diels-Alderase Catalytic Antibody 10F11 by Site-directed Mutagenesis. L. Zheng, J.-P. Goddard, U. Baumann, J.-L. Reymond, J. Mol. Biol. 2004, 341, 807-814.

92. Enzyme assays for high-throughput screening. J.-P. Goddard, J.-L. Reymond, Curr. Opin. Biotechnol. 2004, 15, 314-322.

91. Zinc–proline catalyzed pathway for the formation of sugars. J. Kofoed , M. Machuqueiro, J.-L. Reymond, T. Darbre, Chem. Commun. 2004, 1540-1541.

90. Selective Catalysis with Peptide Dendrimers. C. Douat-Casassus, T. Darbre, J.-L. Reymond, J. Am. Chem. Soc. 2004, 126, 7817-7826.

89. Recent advances in enzyme assays. J.-P. Goddard, J.-L. Reymond., Trend Biotechnol. 2004, 22, 363-370.

88. Classifying Enzymes from Selectivity Fingerprints. J. Grognux, J.-L. Reymond, ChemBioChem 2004, 5, 826-831.

87. Theoretical Investigation of the Origins of Catalysis of a Retro-Diels-Alder Reaction by Antibody 10F11. A. G. Leach, K. N. Houk, J.-L. Reymond, J. Org. Chem. 2004,69, 3683-3692.

86. Fluorescence Assay and Screening of Epoxide Opening by Nucleophiles. F. Badalassi, G. Klein, P. Crotti, J.-L. Reymond, Eur. J. Org. Chem. 2004, 2557-2566.

85. Aldehyde detection by chromogenic/fluorogenic oxime bond fragmentation. S. Salahuddin, O. Renaudet, J.-L. Reymond, Org. Biomol. Chem. 2004, 2, 1471-1475.

84. A Catalytic Antibody against a Tocopherol Cyclase Inhibitor. R. Manetsch, L. Zheng, M. T. Reymond, W.-D. Woggon, J.-L. Reymond, Chem. Eur. J. 2004, 10, 2487-2506.

83. Structure activity relationships in aminocyclopentitol glycosidase inhibitors. L. Gartenmann Dickson, E. Leroy, J.-L. Reymond, Org. Biomol. Chem. 2004, 2, 1217-1226.

82. Molecular Mechanism of Enantioselective Proton Transfer to Carbon in Catalytic Antibody 14D9. L. Zheng, U. Baumann, J.-L. Reymond, Proc. Natl. Acad. Sci. U. S. A. 2004, 101, 3387-3392.

81. Synthesis and Esterolytic Activity of Catalytic Peptide Dendrimers. D. Lagnoux, E. Delort, C. Douat-Casassus, A. Esposito, J.-L. Reymond, Chem. Eur. J. 2004, 10, 1215-1226.

80. Synthesis of Ether Oligomers. O. Renaudet, J.-L. Reymond, Org. Lett. 2004, 6, 397-400.

79. Adrenaline Profiling of Lipases and Esterases with 1,2-Diol and Carbohydrate Acetates. D. Wahler, O. Boujard, F. Lefèvre, J.-L. Reymond, Tetrahedron 2004, 60, 703-710.


78. Iterative Oxime Bond Chemistry Leads to Protease Inhibitors. O. Renaudet, J.-L. Reymond, Org. Lett. 2003, 5, 4693-4696.

77. Fluorogenic Cyanohydrin Esters as Chiral Probes for Esterase and Lipase Activity. E. Leroy, N. Bensel, J.-L. Reymond, Adv. Syn. Catal. 2003, 345, 859-865.

76. b-Aminoalcohol properfumes. Y. Yang, D. Wahler, J.-L. Reymond, Helv. Chim. Acta 2003, 86, 2928-2936.

75. A sensitive and selective high-throughput screening fluorescence assay for lipases and esterases. E. Nyfeler, J. Grognux, D. Wahler, J.-L. Reymond, Helv. Chim. Acta2003, 86, 2919-2927.

74. Synthesis and Evaluation of Chromogenic and Fluorogenic Analogs of Glycerol for Enzyme Assays. E. M. Gonzalez-Garcia, J. Grognux, D. Wahler, J.-L. Reymond, Helv. Chim. Acta 2003, 86, 2458-2470.

73. A green fluorescent chemosensor for amino acids provides a versatile high-throughput screening (HTS) assay for proteases. K. E. S. Dean, G. Klein, O. Renaudet and J.-L. Reymond, Bioorg. Med. Chem. Lett. 2003, 10, 1653-1656.

72. A low background high-Throughput screening (HTS) fluorescence assay for lipases and esterases using acyloxymethylethers of umbelliferone. E. Leroy, N. Bensel and J.-L. Reymond. Bioorg. Med. Chem. Lett. 2003, 13, 2105-2108.

71. Discovery of New Peptide-based Catalysts for the Direct Asymmetric Aldol Reaction. J. Kofoed, J. Nielsen, J.-L. Reymond, Bioorg. Med. Chem. Lett. 2003, 15, 2445-2447.

70. Production of a Functional Catalytic Antibody ScFv-NusA Fusion Protein in the Bacterial Cytoplasm. L. Zheng, U. Baumann, J.-L. Reymond, J. Biochem 2003, 5, 577?81.

69. Catalytic Peptide Dendrimers. A. Esposito, E. Delort, D. Lagnoux, F. Djojo, J.-L. Reymond, Angew. Chem. Int. Ed. 2003, 42, 1381-1383.

68. Fluorogenic Stereochemical Probes for Transaldolases. E. González-García, V. Helaine, G. Klein, M. Schuermann, G. A. Sprenger, W.-D. Fessner, J.-L. Reymond, Chem. Eur. J. 2003, 9, 893-899.


67. Detection Strategies for Catalytic Antibodies. J.-L. Reymond, J. Immunol. Methods 2002, 269, 125-131.

66. High-Throughput Screening of Thermostable Esterases for Industrial Bioconversions. D. Lagarde, H.-K. Nguyen, G. Ravot, D. Wahler, J.-L. Reymond, G.Hills, T. Veit, F. Lefevre, Org. Process. R. & D. 2002,6, 441-5.

65. A selective HIV-Protease Assay Based on a Chromogenic Amino Acid. F. Badalassi, H.-K. Nguyen, P. Crotti, J.-L. Reymond, Helv. Chim. Acta2002, 85, 3090-3098.

64. A structural basis for the activity of retro-Diels-Alder catalytic antibodies: Evidence for a catalytic aromatic residue. M. Hugot, N. Bensel, M. Vogel, M. T. Reymond, B. Stadler, J.-L. Reymond, U. Baumann, Proc. Natl. Acad. Sci. USA 2002, 99, 9674-8.

63. Enzyme Fingerprints of Activity, Stereo- and Enantioselectivity from Fluorogenic and Chromogenic Substrate Arrays. D. Wahler, F. Badalassi, P. Crotti, J.-L. Reymond, Chem. Eur. J. 2002, 8, 3211-3228.

62. Methylamine Adenine Dinucleotide (MAD), a Cofactor to Turn Alcohol Dehydrogenases into Aldolases. D. Wahler, J.-L. Reymond, Can. J. Chem.2002, 80, 665-670.

61. Substrate Arrays as Enzyme Fingerprinting Tools. J.-L. Reymond, D. Wahler, ChemBiochem 2002, 3, 701-708.

60. The Adrenaline Test for Enzymes. D. Wahler, J.-L. Reymond, Angew. Chem. Int. Ed. Engl.2002, 41, 1229-1232.


59. New High-Throughput Screening Assays for Biocatalysis. J.-L. Reymond, Chimia 2001, 55, 1049.

58. High-Throughput Screening for Biocatalysts. D. Wahler, J.-L. Reymond, Curr. Opin. Biotechnol. 2001, 12, 535.

57. Enzyme Fingerprints by Fluorogenic and Chromogenic Substrate Arrays. D. Wahler, F. Badalassi, P. Crotti, J.-L. Reymond, Angew. Chem. Int. Ed. Engl. 2001, 40, 4457.

56. Exploring Biocatalysis Using Catalytic Antibodies. J.-L. Reymond, Chimia 2001, 55, 330.

55. Aminocyclopentitol Inhibitors of a-L-Fucosidases. A. Blaser, J.-L. Reymond, Helv. Chim. Acta2001, 2119.

54. Pivalase Catalytic Antibodies: Towards Abzymatic Activation of Prodrugs. N. Bensel, M. T. Reymond, J.-L. Reymond, Chem. Eur. J. 2001, 7, 4604.

53. Enantioselective Epoxidation with a Library of Catalytic Antibodies. Y. Chen, J.-L. Reymond, Synthesis 2001, 934.

52. A Fluorescent Metal Sensor Based on Macrocyclic Chelation. G. Klein, D. Kaufmann, S. Schürch, J.-L. Reymond, Chem. Commun.2001, 561.

51. An Enzyme Assay using pM. G. Klein, J.-L. Reymond, Angew. Chem. 2001, 113, 1821.

50. Novel Methods for Biocatalysts Screening. D. Wahler, J.-L. Reymond, Curr. Opin. Chem. Biol. 2001, 5, 152.


49. A Versatile Periodate-Coupled Fluorogenic Assay for Hydrolytic Enzymes. F. Badalassi, D. Wahler, G. Klein, P. Crotti, J.-L. Reymond, Angew. Chem. Int. Ed.Engl. 2000, 39, 4067.

48. Stereoselective Inhibition of a-L-Fucosidases by N-Benzyl Aminocyclopentitols. A. Blaser, J.-L. Reymond, Org. Lett. 2000, 2, 1733.

47. Stereoselective Synthesis of an Aminocyclopentitol Analog of a-L-Fucose via an Allylic Bromohydrin. A. Blaser, J.-L. Reymond, Synlett 2000, 6, 817.

46. Fluorogenic Polypropionate Fragments for Detecting Stereoselective Aldolases. R. Pérez Carlón, N. Jourdain, J.-L. Reymond, Chem. Eur. J. 2000, 6, 4154.

45. Atropisomeric Transition State Analogs. O. Ritzeler, S. Parel, B. Therrien, N. Bensel, J.-L. Reymond, K. Schenk, Eur. J. Org. Chem. 2000, 1365.

44. Synthesis and Evaluation of Amino-Cyclopentitol Inhibitors of b -Glucosidases. O. Boss, E. Leroy, A. Blaser, J.-L. Reymond, Org. Lett. 2000, 2, 151.


43. Atropisomeric Transition State Analogs. O. Ritzeler, G. Klein, J.-L. Reymond, Phosphor Sulfur Silicon. 1999, 146, 243.

42. Anomer-selective Inhibition of Glycosidases using Amino-cyclopentanols. E. Leroy, J.-L. Reymond, Org. Lett. 1999, 1, 775.

41. Phosphofurylalanine, a Stable Analog of Phosphohistidine. C. Schenkels, B. Erni, J.-L. Reymond, Bioorg. Med. Chem. Lett. 1999, 1443.

40. A Selective a-L-Fucosidase Inhibitor Based on an Aminocyclopentane Framework. A. Blaser, J.-L. Reymond, Helv. Chim. Acta 1999, 82, 760.

39. Enantioselective Fluorogenic Assay of Acetate Hydrolysis for Detecting Lipase Catalytic Antibodies. G. Klein, J.-L. Reymond, Helv. Chim. Acta 1999, 82, 400.

38. Catalytic Antibodies by Fluorescence Screening. N. Bensel, N. Bahr, M. T. Reymond, C. Schenkels and J.-L. Reymond, Helv. Chim. Acta 1999, 82, 44.

37. A General Fluorogenic Assay for Catalysis Using Antibody Sensors. P. Geymayer, N. Bahr and J.-L. Reymond, Chem. Eur. J. 1999, 5, 1006.

36. Catalytic Antibodies for Organic Synthesis. J.-L. Reymond, Top. Curr. Chem. 1999, 200, 59.


35. A Stereoselective Fluorogenic Assay for Aldolases: Detection of an anti-selective Aldolase Catalytic Antibody. N. Jourdain, R. Pérez-Carlón, J.-L. Reymond, Tetrahedron Lett. 1998, 39, 9415.

34. Enantioselectivity vs. Kinetic Resolution in Antibody Catalysis: Formation of the (S) product despite preferential binding of the (R) Intermediate. D. Shabat, H. Shulman, H. Itzhaky, J.-L. Reymond, E. Keinan, Chem. Commun. 1998, 1759.

33. Stereoselectivity of Aldolase Catalytic Antibodies. J.-L. Reymond, J. Mol. Cat. B 1998, 5, 331.

32. An Enantioselective Fluorimetric Assay for Alcohol Dehydrogenases Using Albumin-Catalyzed b-Elimination of Umbelliferone. G. Klein, J.-L. Reymond, Bioorg. Med. Chem. Lett. 1998, 8, 1113.

1988 - 1997

31. Design and Synthesis of Transition State Analogs for Induction of Hydride Transfer Catalytic Antibodies. J. Schröer, M. Sanner, J.-L. Reymond, R. A. Lerner, J. Org. Chem. 1997, 62, 3220.

30. Highly Photoresistant Chemosensors Using Acridone as Fluorescent Label. N. Bahr, E. Tierney, J.-L. Reymond, Tetrahedron Letters 1997, 38, 1489.

29. Asymmetric Organic Synthesis with Catalytic Antibodies. E. Keinan, S. C. Sinha, D. Shabat, H. Itzhaky, J.-L. Reymond, Acta Chem. Scand. 1996, 50, 679.

28. Antibody-Catalyzed Uni- And Multi-Substrate Reactions Compared Using Transition State Binding (KTS). J.-L. Reymond, Y. Chen, Isr. J. Chem. 1996, 36, 199.

27. Catalytic Antibodies as Probes of Evolution: Modelling of a Primordial Glycosidase. D. Shabat, S. C. Sinha, J.-L. Reymond, E. Keinan, Angew. Chem. Intl. Ed. Engl.1996, 35, 2628.

26. A Nitroxyl Synthase Catalytic Antibody. N. Bahr, R. Güller, J.-L. Reymond, R. A. Lerner, J. Am. Chem. Soc. 1996, 118, 3550.

25. A General Assay for Antibody Catalysis using Acridone as a Fluorescent Tag. J.-L. Reymond, T. Koch, J. Schröer, E. Tierney, Proc. Natl. Acad. Sci. USA 1996, 93, 4251.

24. Catalytic, Enantioselective Aldol Reaction with an Artificial Aldolase Assembled from a Primary Amine and an Antibody. J.-L. Reymond, Y. Chen, J. Org. Chem. 1995, 6970.

23. Antibody Catalysis of Multistep Reactions: an Aldol Addition Followed by a Disfavored Elimination. T. Koch, J.-L. Reymond, R. A. Lerner, J. Am. Chem. Soc. 1995, 117, 9383.

22. (S)-Enantioselective Retroaldol Reaction and (R)-Enantioselective b-Elimination with an Aldolase Catalytic Antibody. J.-L. Reymond, Angew. Chem. Int. Ed. Engl. 1995, 34, 2285.

21. Epoxidation of Olefins with Formamide - Hydrogen Peroxide. Y. Chen, J.-L. Reymond, Tetrahedron Letters 1995, 36, 4015.

20. Catalytic, Enantioselective Aldol Reaction Using Antibodies against a Quaternary Ammonium Ion with a Primary Amine Cofactor. J.-L. Reymond, Y. Chen, Tetrahedron Letters 1995, 36, 2575.

19. Antibody Catalysis of a Reaction Otherwise Strongly Disfavored in Water. D. Shabat, H. Itzhaky, J.-L. Reymond, E. Keinan, Nature 1995, 374, 143.

18. Structure of the Antibody - Transition State Complex and Origin of the Enantioselectivity. G. K. Jahangiri, J.-L. Reymond, J. Am. Chem. Soc. 1994, 116, 11264.

17. An Antibody-Catalyzed 1,2-Rearrangement of Carbon-Carbon Bonds. Y. Chen, J.-L. Reymond, R. A. Lerner, Angew. Chem. Int. Ed. Engl. 1994, 33, 1607.

16. Enantioselective, Multigram-Scale Synthesis with a Catalytic Antibody. J.-L. Reymond, J.-L. Reber, R. A. Lerner, Angew. Chem. Int. Ed. Engl. 1994, 33, 475.

15. Antibody-Catalyzed Activation of Unfunctionalized Olefins for Highly Enantioselective Asymmetric Epoxidation. A. Koch, J.-L. Reymond, R. A. Lerner, J. Am. Chem. Soc. 1994, 116, 803.

14. Antibody-Catalyzed Reversal of Chemoselectivity. S. C. Sinha, E. Keinan, J.-L. Reymond, Proc. Natl. Acad. Sci. USA 1993, 90, 11910.

13. Antibody-Catalyzed Enantioselective Epoxide Hydrolysis. S. C. Sinha, E. Keinan, J.-L. Reymond, J. Am. Chem. Soc. 1993, 115, 4893.

12. Antibody-Catalyzed Hydrolysis of Enol Ethers. J.-L. Reymond, G. K. Jahanghiri, R. A. Lerner, J. Am. Chem. Soc. 1993, 115, 3909.

11. Highly Enantioselective Protonation Catalyzed by an Antibody. J.-L. Reymond, K. D. Janda, R.A. Lerner, J. Am. Chem. Soc. 1992, 114, 2257.

10. Antibody Catalysis of Glycosidic Bond Hydrolysis. J.-L. Reymond, K. D. Janda, R. A. Lerner, Angew. Chem. Int. Ed. Engl. 1991, 30, 1711.

9. Highly Stereoselective Synthesis of (+/-)-Aminobromocyclitol Derivatives from Furan. E. Reynard, J.-L. Reymond, P. Vogel, Synlett 1991, 470.

8. Total, Asymmetric Syntheses of (+)-Castanospermine, (+)-6-Deoxycastanospermine and (+)-6-Deoxy-6-fluorocastanospermine. J.-L. Reymond, A. A. Pinkerton, P. Vogel, J. Org. Chem. 1991, 56, 2128.

7. Stereoselective Syntheses of Protected Amino-hydroxy-cyclopentane-carbaldehyde Derivatives from 7-Oxabicyclo[2.2.1]hept-5-en-2-yl Systems. J.-L. Reymond, P. Vogel, Chimia 1990, 44, 342.

6. New Chiral Auxiliaries and New Optically Pure Ketene Equivalents Derived from Tartaric Acids. Improved Synthesis of (-)-7-Oxabicyclo[2.2.1]hept-5-en-2-one. J.-L. Reymond, P. Vogel, Tetrahedron: Asymmetry 1990, 1, 729.

5. Application of New Optically Pure Ketene Equivalents Derived from Tartaric Acids to the Total, Asymmetric Syntheses of (+)-6-Deoxycastanospermine and (+)-6-Deoxy-6-fluoro castanospermine. J.-L. Reymond, P. Vogel, J. Chem. Soc. Chem. Commun. 1990, 1070.

4. Acid Promoted Rearrangements of N-Substituted 8-Oxa-3-azatricyclo[,4]octane-6,7-dicarboxylates: Remote Substituent Effects on the Regioselectivity of the N-Acylaziridine/dihydrooxazone Rearrangement. S. Allemann, J.-L. Reymond, P. Vogel, Helv. Chim. Acta 1990, 73, 674.

3. Acid-catalyzed Rearrangements of 3-Aza-8-oxabicyclo[,4]oct-6-one Acetals. Highly Stereoselective Total Synthesis of 3-Amino-3-deoxy-D-altrose and Derivatives. C. Nativi, J.-L. Reymond, P. Vogel, Helv. Chim. Acta 1989, 72, 882.

2. A highly Stereoselective Synthesis of Castanospermine. J.-L. Reymond, P. Vogel, Tetrahedron Letters 1989, 30, 705.

1. Stereoselective amino-hydroxylation of the double bond in 7-oxabicyclo[2.2.1]hept-5-en-2-yl derivatives. Remote substituent participation in acid-catalyzed decompositions of aziridines and triazolines. J.-L. Reymond, P. Vogel, Tetrahedron Letters 1988, 29, 3695.

Ph.D.-theses with Prof. Reymond


72. Kleni Mulliri, 2023. Design and Synthesis of Heterocyclic Compounds with Potential Biological Activity Derived from GDB Databases.

71. Hippolyte Personne, 2023. Design, Synthesis and Structural Determination of Antimicrobial Peptides and Peptidomimetics.

70. David Kreutter, 2023. Towards Sustainable Synthesis: Integrating Biocatalysis and Language Models in Computer-Aided Synthesis Planning.

69. Mario De Capitani, 2023. Customised Isoprenoid Lipids and Carbohydrate Building Blocks for Natural Product Mimics.

68. Aline Carrel, 2023. Exploring Bicyclic Diamines as Drug Scaffolds.


67. Sven Bühlmann, 2022. The Generated Database GDB20.

66. Elena Zakharova, 2022. Anticancer Activity of Non-hemolytic Membrane Disruptive Peptides/Peptide Dendrimers.

65. Xingguang Cai, 2022. Drug Discovery and Mechanism Study of Antimicrobial Peptides.

64. Amol Thakkar, 2022. Computer Aided Synthesis Prediction to Enable Augmented Chemical Discovery and Chemical Space Exploration.


63. Dina Erzina, 2021. Immunomodulatory Peptide Dendrimers Inspired from Glatiramer Acetate.

62. Alice Capecchi, 2021. Cheminformatics Tools to Explore the Chemical Space of Peptides and Natural Products.

61. Philippe Schwaller, 2021. Learning the Language of Chemical Reactions – Atom by Atom. Linguistics-Inspired Machine Learning Methods for Chemical Reaction Tasks.

60. Susanna Zamolo, 2021. Synthesis and Mechanistic Study of New Peptide Dendrimers as Transfection Reagents for pDNA.


59. Giorgio Pesciullesi, 2020. Synthesis of Lipid Linked Oligosaccharides to Probe Enzymatic Glycosylation.

58. Josep Arús-Pous, 2020. Exploring the Chemical Space Using Enumerative and Deep Learning Approaches.

57. Kris Meier, 2020. Synthesis of GDB-Derived Tricyclic Scaffolds for Medicinal Chemistry.

56. Daniel Probst, 2020. Scalable Methods for the Exploration and Visualization of Large Chemical Spaces.

55. Stéphane Baeriswyl, 2020. Design and X-ray Structure Determination of Antimicrobial Peptides.


54. Bee-Ha Gan, 2019. Imaging the Mode of Action of Peptide Dendrimers.

53. Marion Poirier, 2019. Targeting membrane transport with small molecules.

52. Clémence Delalande, 2019. Chemical space guided discovery of selective TRPM4 and NHE9 inhibitors.


51. Thissa N. Siriwardena, 2018. Discovery of novel antimicrobial peptide dendrimers active against multidrug-resistant bacteria.

50. Marc Heitz, 2018. Peptide dendrimers as nucleic acid transfection reagents.

49. Ivan Di Bonaventura, 2018. Design, synthesis and characterization of antimicrobial bicyclic peptides.


48. Jérémy Boilevin, 2017. Synthesis of lipid-linked oligosaccharide substrates and inhibtors of protein N-Glycosylation enzymes.

47. Ricardo Visini, 2017. Cheminformatic and structural biology insights into small molecule fragments, ring systems and peptides.


46. Runze He, 2016. Design of short cyclic and linear antimicrobial peptides targeting multi-drug resistant bacteria.

45. Xian Jin, 2016. Molecular Fingerprints for the Analysis of Proteins in 3D-shape Space and Their Application for Peptide Design.


44. Gaëlle Michaud, 2015. Exploration of Multivalent Glycopeptide Dendrimers as Inhibitors against Pseudomonas aeruginosa Biofilms.

43. Falco Kilchmann, 2015. Novel Inhibitors for the Kinase Aurora-A.

42. Céline Simonin, 2015. Targeting Ion Channels and Transporters with Small Molecules: an Integrated Virtual Screening and Synthesis Approach.

41. Mahendra Awale, 2015. Interactive Chemical Space Visualization and Virtual Screening for Drug Discovery.


40. Marco Bartoloni, 2014. Design, synthesis and structure analysis of bicyclic bridged peptides.

39. Michaela Stach, 2014. Discovery and Optimization of Antimicrobial Peptide Dendrimers against Pseudomonas aeruginosa.

38. Julian Schwartz, 2014. New Tools and Methods for Virtual Screening of Small Molecules and Peptides.

37. Myriam Bergmann, 2014. Multivalent Glycopeptide Dendrimers as Pseudomonas aeruginosa Biofilm Inhibitors.


36. Justus Bürgi, 2013. Design, Synthesis and Characterization of Small Molecules Modulating Nicotinic Acetylcholine Receptors.

35. Gabriela Andrea Eggimann, 2013. Peptide Dendrimers with Cell Penetrating and Gene Transfection Properties.

34. Lars Ruddigkeit, 2013. Assembly, Analysis and Application of the Chemical Universe Database GDB-17.


33. Nicolas Uhlich, 2011. Convergent Synthesis of Protein-Sized Peptide Dendrimers.

32. Rasomoy Biswas, 2011. Glycopeptide Dendrimers for Drug Delivery and a Comparative Esterase Activity Study between Linear and Dendritic Peptides.

31. Lorenz Christian Blum, 2011. Assembly, Analysis and Application of the Chemical Universe Database GDB-13.

30. Rameshwar Kadam, 2011. Structure and Dynamics of Peptide Dendrimers.


29. Erika Luethi, 2010. Mining the Chemical Universe Database GDB for New Bioactive Aspartate, Glutamate and Peptide Analogues.

28. Ruud van Deursen, 2010. Computation Methods for Mapping and Scoring Chemical Space towards Drug Discovery.#

27. Noélie Maillard, 2010. Development of an Off-Bead Screening to Discover Catalysts and New Antimicrobial Peptide Dendrimers

26. Viviana S. Fluxa Rojas, 2010. Combinatorial Discovery of Antimicrobial Cyclic Peptide Analogues of Tyrocidine A, Gramicidin S and Daptomycin.


25. Kong Thong Nguyen, 2009. Ligand Discovery from the Chemical Universe Database

24. Emma M. V. Johansson, 2009. Combinatorial Discovery of Glycopeptide Dendrimers Targeting Lectins.


23. Sacha Javor, 2008. Peptide Dendrimers as Enzyme Mimics.


22. Peter Sommer, 2007. Combinatorial Discovery and Investigation of Peptide Dendrimers Models for the Vitamin B12 and Heme Binding Proteins.

21. Salahuddin Syed, 2007. Synthesis and Discovery of Bioactive Small Molecule from the Chemical Universe Database (GDB).


20. Peter Babiak, 2006. Lipase and esterase screening and fingerprinting.

19. Jacob Kofoed, 2006. Peptide Dendrimers and Zinc-Proline as Artificial Aldolases: Mimicking Nature's Approach to Carbon-Carbon Bond Formation.

18. Renaud Sicard, 2006.
Part I: New high-throughput screening and fingerprinting assays for microbial enzymes. Part II: Evaluation of cytotoxic glycopeptide dendrimer conjugates of Taxol and Colchicine.

17. Tobias Fink, 2006. The Chemical Universe of Small Molecules.


16. Johann Grognux, 2005. Fluorescence Assays for Fingerprinting Lipases in Solution and on Microarray.

15. Anthony Clouet, 2005. Discovery of New Functional Peptide Dendrimers as Enantioselective Catalyts and Hosts for Vitamin B12.

14. Estelle Delort, 2005. Catalytic Peptide Dendrimers as Artificial Enzymes: from Rational Design to Combinatorial Approach.

13. Yongzheng Yang, 2005. Enzyme Activity Fingerprinting with Peptide Cocktail and Substrate Cocktail.


12. David Lagnoux, 2004. Glycopeptide Dendrimer Drug Conjugates.

11. Lucas Gartenmann, 2004. Synthesis and Activity of Glycosidase Inhibitors and their Use as Haptens.


10. Lei Zheng, 2003. Structure and Function Relationships of Catalytic Antibodies Studied by X-Ray Crystallography and Site-Directed Mutagenesis and Computer Modelling.


9. Eva-Maria Gonzalez Garcia 2002. Synthesis of New Fluoro / Chromogenic Enzyme Substrates and Implementation in Screening Transaldolases and Lipases.

8. Marina Hugot, 2002. Structure-Activity Relationships in Nitroxyl-Synthase Catalytic Antibodies.

7. Emmanuel Leroy, 2002. Design and Synthesis of New α –andβ-Galactosidase Inhibitors.

6. Denis Wahler, 2002. Substrate Arrays for Enzyme Fingerprinting.


5. Caroline Schenkels, 2001. Chemistry and Biology of Phosphohistidine Analogs.

4. Nathalie Jourdain, 2001. Chemical Approaches for the Design, Screening and Selection of Artificial Biocatalysts.

3. Gérard Klein, 2001. Cinq Nouvelles Méthodes de Criblage ?Haut Débit pour des Enzymes Enantiosélectives et leur Application aux Anticorps Catalytiques.

2. Nicolas Bensel, 2001. Activation de Prodrogues du NO par les Anticorps Catalytiques.

1. Adrian Blaser, 2001. Aminocyclopentitol Inhibitors of α-L-Fucosidase and their Use as Haptens.