Our paper An intrinsically disordered antimicrobial peptide dendrimer from stereorandomized virtual screening is published in Cell Reports Physical Science! Highlights: • Stereorandomized antimicrobial peptide dendrimers are identified by virtual screening • A switch to L residues induces α-helical folding and strong toxicity in one
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The paper of Ana S. Ramírez (Kaspar P. Locher’s Lab) collaborating with our group is now published in Nature Communications! We chemo-enzymatically produced an LLO analog carrying the native oligosaccharide and obtained cryo-EM structures of yeast OST in different functional states.
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The paper of Johannes Morstein collaborating with our group on the role of lipidation in cell permeability is now published in JACS! Check it out: Medium-Chain Lipid Conjugation Facilitates Cell-Permeability and Bioactivity Abstract: The majority of bioactive molecules act on membrane proteins
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The 2022 Swiss Summer School on Chemical Biology successfully took place on on Sept 11-15, in Les Diablerets, Switzerland. Here, we thank all the contributions from the Reymond group!
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The SCS Fall Meeting 2022 successfully took place on September 8 at University Zurich! The SCS Fall Meeting is the major regularly organized event of the Swiss Chemical Society and one of the largest annual research conferences in Switzerland. For decades, the
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Congratulations to our group member Hippolyte Personne winning one of the three Best Poster Presentation Awards at the Peptide Therapeutics Forum Basel 2022! Poster topic: X-ray Structures of Mixed-chirality α-Helical Antimicrobial Peptides Check more information: https://ptf22.scg.ch
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Our paper Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening is now published online in RSC Chemical Science! This work reports the use of in-house built 3D (xLOS) and 2D (Xfp)
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Our paper Machine Learning Guided Discovery of Non-Hemolytic Membrane Disruptive Anticancer Peptides is now published in ChemMedChem! Abstract: Most antimicrobial peptides (AMPs) and anticancer peptides (ACPs) fold into membrane disruptive cationic amphiphilic α-helices, many of which are however also unpredictably hemolytic and
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Our paper Rotavirus Spike Protein VP4 Mediates Viroplasm Assembly by Association to Actin Filaments is now published in Journal of Virology! The Institute of Virology, Zurich in collaboration with us performed this research study. With a peptide mimicking loop K145-G150 of VP4
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