Reymond Research Group

University of Bern

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Synthesis and characterisation of fluorescent substrates for eukaryotic protein N-glycosylation

Synthesis and characterisation of fluorescent substrates for eukaryotic protein N-glycosylation

The paper Synthesis and characterisation of fluorescent substrates for eukaryotic protein N-glycosylation is now available online in Tetrahedron! Check it out: https://www.sciencedirect.com/science/article/pii/S0040402023001436 Keywords: Carbohydrates; Fluorescence; Dolichol; Chitobiose; Mannose; Protein glycosylation Abstract: Herein we report the synthesis of two fluorescently labelled analogues of C25
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Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis

Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis

The paper Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis is now published in ACS Omega! Check it out: Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis Abstract: Herein, we report dipropylamine (DPA) as a fluorenylmethyloxycarbonyl (Fmoc) deprotection reagent to
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Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase

Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase

Our paper Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase is published in Nature Chemical Biology! Abstract: C-linked glycosylation is essential for the trafficking, folding and function of secretory and transmembrane proteins involved in cellular communication processes. The tryptophan C-mannosyltransferase (CMT) enzymes that install the modification attach a mannose to
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An intrinsically disordered antimicrobial peptide dendrimer from stereorandomized virtual screening

An intrinsically disordered antimicrobial peptide dendrimer from stereorandomized virtual screening

Our paper An intrinsically disordered antimicrobial peptide dendrimer from stereorandomized virtual screening is published in Cell Reports Physical Science! Highlights: • Stereorandomized antimicrobial peptide dendrimers are identified by virtual screening • A switch to L residues induces α-helical folding and strong toxicity in one sr-AMPD • Another AMPD remains intrinsically disordered, active, and
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Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening

Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening

Our paper Discovery of novel drug-like antitubercular hits targeting the MEP pathway enzyme DXPS by strategic application of ligand-based virtual screening is now published online in RSC Chemical Science! This work reports the use of in-house built 3D (xLOS) and 2D (Xfp) ligand based virtual screeining approaches (LBVS) for the
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