Reymond Research Group

University of Bern

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Molecular basis of lipid-linked oligosaccharide recognition and processing by bacterial oligosaccharyltransferase

Molecular basis of lipid-linked oligosaccharide recognition and processing by bacterial oligosaccharyltransferase

The paper Molecular basis of lipid-linked oligosaccharide recognition and processing by bacterial oligosaccharyltransferase has been published by Nature Structural and Molecular Biology. Oligosaccharyltransferase (OST) is a membrane-integral enzyme that catalyzes the transfer of glycans from lipid-linked oligosaccharides (LLOs) onto asparagine side chains, the first step in protein N-glycosylation. Here, we
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Design, crystal structure and AFM study of thioether ligated D,L-cyclic antimicrobial peptides against multidrug resistant Pseudomonas aeruginosa
Publications

Design, crystal structure and AFM study of thioether ligated D,L-cyclic antimicrobial peptides against multidrug resistant Pseudomonas aeruginosa

The paper Design, crystal structure and atomic force microscopy study of thioether ligated D,L-cyclic antimicrobial peptides against multidrug resistant Pseudomonas aeruginosa has been accepted for publication by Chemical Science. Here we report a new family of cyclic antimicrobial peptides (CAMPs) targeting MDR strains of Pseudomonas aeruginosa. These CAMPs are
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Plotting a course to new antibiotics: Mapping out the chemical space of peptide antibiotics offers an efficient way to find new compounds
News

Plotting a course to new antibiotics: Mapping out the chemical space of peptide antibiotics offers an efficient way to find new compounds

A news article on the groups recent paper Chemical space guided discovery of antimicrobial bridged bicyclic peptides against Pseudomonas aeruginosa and its biofilms has been published by the monthly chemistry news magazine Chemistry World, which in turn is published by the Royal Society of Chemistry. The article, written by Alexander
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Chemical Space Guided Discovery of Antimicrobial Bridged Bicyclic Peptides Against Pseudomonas aeruginosa and its Biofilms
Publications

Chemical Space Guided Discovery of Antimicrobial Bridged Bicyclic Peptides Against Pseudomonas aeruginosa and its Biofilms

The paper Chemical Space Guided Discovery of Antimicrobial Bridged Bicyclic Peptides Against Pseudomonas aeruginosa and its Biofilms has been accepted for publication by Chemical Sciences. Herein we report the discovery of antimicrobial bridged bicyclic peptides (AMBPs) active against Pseudomonas aeruginosa, a highly problematic Gram negative bacterium in the hospital environment.
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Chemo-enzymatic synthesis of lipid-linked GlcNAc2Man5 oligosaccharides using recombinant Alg1, Alg2 and Alg11 proteins
Publications

Chemo-enzymatic synthesis of lipid-linked GlcNAc2Man5 oligosaccharides using recombinant Alg1, Alg2 and Alg11 proteins

The paper Chemo-enzymatic synthesis of lipid-linked GlcNAc2Man5 oligosaccharides using recombinant Alg1, Alg2 and Alg11 proteins has been accepted for publication by Glycobiology. The biosynthesis of eukaryotic lipid-linked oligosaccharides (LLOs) that act as donor substrates in eukaryotic protein N-glycosylation starts on the cytoplasmic side of the endoplasmic reticulum and includes the
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Characterization of the single-subunit oligosaccharyltransferase STT3A from Trypanosoma brucei using synthetic peptides and ...

Characterization of the single-subunit oligosaccharyltransferase STT3A from Trypanosoma brucei using synthetic peptides and ...

The paper Characterization of the single-subunit oligosaccharyltransferase STT3A from Trypanosoma brucei using synthetic peptides and lipid-linked oligosaccharide analogs has been published in the journal Glycobiology. The initial transfer of a complex glycan in protein N-glycosylation is catalyzed by oligosaccharyltransferase (OST), which is generally a multi-subunit membrane protein complex in the
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The polypharmacology browser: a web-based multi-fingerprint target prediction tool using ChEMBL bioactivity data

The polypharmacology browser: a web-based multi-fingerprint target prediction tool using ChEMBL bioactivity data

The paper The polypharmacology browser: a web-based multi-fingerprint target prediction tool using ChEMBL bioactivity data has been published in Journal of Cheminformatics. Background Several web-based tools have been reported recently which predict the possible targets of a small molecule by similarity to compounds of known bioactivity using molecular fingerprints (fps)
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Improved fluorescence assays to measure the defects associated with F508del-CFTR allow identification of new active compounds
Publications

Improved fluorescence assays to measure the defects associated with F508del-CFTR allow identification of new active compounds

The paper Improved fluorescence assays to measure the defects associated with F508del-CFTR allow identification of new active compounds has been published by the British Journal of Pharmacology. Cystic fibrosis (CF) is a debilitating disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which codes for a
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Fluorescent Agonists of the α7 Nicotinic Acetylcholine Receptor Derived from 3-Amino-Quinuclidine
Publications

Fluorescent Agonists of the α7 Nicotinic Acetylcholine Receptor Derived from 3-Amino-Quinuclidine

The paper Fluorescent Agonists of the α7 Nicotinic Acetylcholine Receptor Derived from 3-Amino-Quinuclidine has been accepted for publication by Helvetica Chemica Acta. Here we asked the question whether fluorescence labelled small molecule agonists of the α7 nicotinic acetylcholine receptor (nAChR) might be identified to enhance receptor studies. Enantiomerically pure 3-amino-quinuclidines
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