Ye Buehler

Multistep retrosynthesis combining a disconnection aware triple transformer loop with a route penalty score guided tree search

Multistep retrosynthesis combining a disconnection aware triple transformer loop with a route penalty score guided tree search

Check out our latest paper Multistep retrosynthesis combining a disconnection aware triple transformer loop with a route penalty score guided tree search in Chemical Science! Abstract Computer-aided synthesis planning (CASP) aims to automatically learn organic reactivity from literature and perform retrosynthesis of unseen molecules. CASP systems must learn reactions sufficiently
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Synthesis and characterisation of fluorescent substrates for eukaryotic protein N-glycosylation

Synthesis and characterisation of fluorescent substrates for eukaryotic protein N-glycosylation

The paper Synthesis and characterisation of fluorescent substrates for eukaryotic protein N-glycosylation is now available online in Tetrahedron! Check it out: https://www.sciencedirect.com/science/article/pii/S0040402023001436 Keywords: Carbohydrates; Fluorescence; Dolichol; Chitobiose; Mannose; Protein glycosylation Abstract: Herein we report the synthesis of two fluorescently labelled analogues of C25
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Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis

Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis

The paper Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis is now published in ACS Omega! Check it out: Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis Abstract: Herein, we report dipropylamine (DPA) as a fluorenylmethyloxycarbonyl (Fmoc) deprotection reagent to
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Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase

Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase

Our paper Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase is published in Nature Chemical Biology! Abstract: C-linked glycosylation is essential for the trafficking, folding and function of secretory and transmembrane proteins involved in cellular communication processes. The tryptophan C-mannosyltransferase (CMT) enzymes that install the modification attach a mannose to
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An intrinsically disordered antimicrobial peptide dendrimer from stereorandomized virtual screening

An intrinsically disordered antimicrobial peptide dendrimer from stereorandomized virtual screening

Our paper An intrinsically disordered antimicrobial peptide dendrimer from stereorandomized virtual screening is published in Cell Reports Physical Science! Highlights: • Stereorandomized antimicrobial peptide dendrimers are identified by virtual screening • A switch to L residues induces α-helical folding and strong toxicity in one sr-AMPD • Another AMPD remains intrinsically disordered, active, and
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