Ye Buehler

Multistep retrosynthesis combining a disconnection aware triple transformer loop with a route penalty score guided tree search

Multistep retrosynthesis combining a disconnection aware triple transformer loop with a route penalty score guided tree search

Check out our latest paper Multistep retrosynthesis combining a disconnection aware triple transformer loop with a route penalty score guided tree search in Chemical Science! Abstract Computer-aided synthesis planning (CASP) aims to automatically learn organic reactivity from literature and perform retrosynthesis of unseen molecules. CASP systems must learn reactions sufficiently
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Synthesis and characterisation of fluorescent substrates for eukaryotic protein N-glycosylation

Synthesis and characterisation of fluorescent substrates for eukaryotic protein N-glycosylation

The paper Synthesis and characterisation of fluorescent substrates for eukaryotic protein N-glycosylation is now available online in Tetrahedron! Check it out: https://www.sciencedirect.com/science/article/pii/S0040402023001436 Keywords: Carbohydrates; Fluorescence; Dolichol; Chitobiose; Mannose; Protein glycosylation Abstract: Herein we report the synthesis of two fluorescently labelled analogues of C25
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Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis

Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis

The paper Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis is now published in ACS Omega! Check it out: Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis Abstract: Herein, we report dipropylamine (DPA) as a fluorenylmethyloxycarbonyl (Fmoc) deprotection reagent to
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Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase

Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase

Our paper Structure, sequon recognition and mechanism of tryptophan C-mannosyltransferase is published in Nature Chemical Biology! Abstract: C-linked glycosylation is essential for the trafficking, folding and function of secretory and transmembrane proteins involved in cellular communication processes. The tryptophan C-mannosyltransferase (CMT) enzymes that install the modification attach a mannose to
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