The paper An Antimicrobial Bicyclic Peptide from Chemical Space Against Multidrug Resistant Gram-Negative Bacteria has been accepted for publication by Chemical Communications.

We used the concept of chemical space to explore a virtual library of bicyclic peptides formed by double thioether cyclization of a precursor linear peptide, and identified an antimicrobial bicyclic peptide (AMBP) with remarkable activity against several MDR strains of Acinetobacter baumannii and Pseudomonas aeruginosa.

Author(s): Ivan Dibonaventura, Stéphane Baeriswyl, Alice Capecchi, Bee-Ha Gan, Xian Jin, Thissa Nuwan Siriwardena, Runze He, Thilo Kohler, Arianna Pompilio, Giovanni Di Bonaventura, Christian van Delden, Sacha Javor and Jean-Louis Reymond