Reymond Research Group

The paper Improved fluorescence assays to measure the defects associated with F508del-CFTR allow identification of new active compounds has been published by the British Journal of Pharmacology. Cystic fibrosis (CF) is a debilitating disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which codes for a

The paper Efficient Transfection of siRNA by Peptide Dendrimer–Lipid Conjugates is now published in the journal ChemBioChem. Efficient delivery of small interfering RNA (siRNA) into cells is the basis of target-gene-specific silencing and, ultimately, gene therapy. However, current transfection reagents are relatively inefficient, and very few studies provide the

The paper BIGCHEM: Challenges and Opportunities for Big Data Analysis in Chemistry has been accepted for publication by Molecular Informatics. The increasing volume of biomedical data in chemistry and life sciences requires the development of new methods and approaches for their handling. Here, we briefly discuss some challenges and opportunities

The paper Fluorescent Agonists of the α7 Nicotinic Acetylcholine Receptor Derived from 3-Amino-Quinuclidine has been accepted for publication by Helvetica Chemica Acta. Here we asked the question whether fluorescence labelled small molecule agonists of the α7 nicotinic acetylcholine receptor (nAChR) might be identified to enhance receptor studies. Enantiomerically pure 3-amino-quinuclidines

The paper Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening has been accepted for publication in the Journal of Medicinal Chemistry. Here we report the discovery of a selective inhibitor of Aurora A, a key regulator of cell division and potential anti-cancer target. We used atom category