Reymond Research Group

University of Bern

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New Group Member

Ye Buehler

Feb 7, 2023

The Reymond Research Group would like to welcome its new group member: Yves Grandjean (Ph.D. Student).

Chemical Space for Peptide-based Antimicrobials

Check out our latest review Chemical Space for Peptide-based Antimicrobials in CHIMIA! Abstract Multidrug-resistant (MDR) bacteria represent a global public health threat, and antimicrobial peptides (AMPs), derived from naturally occurring linear or cyclic peptides, can provide the solution. However, most AMPs are sensitive to proteases and have poor pharmacokinetics. The

Nov 1, 2024 1 min read

Stereorandomized Oncocins with Preserved Ribosome Binding andAntibacterial Activity

Check out our latest paper Stereorandomized Oncocins with Preserved Ribosome Binding andAntibacterial Activity in Journal of Medicinal Chemistry! Abstract We recently showed that solid-phase peptidesynthesis using racemic amino acids yields stereorandomizedpeptides comprising all possible diastereomers as homogeneous,single-mass products that can be purified by HPLC and thatstereorandomization modulates activity, toxicity,

Oct 25, 2024 1 min read

Navigating a 1E+60 Chemical Space of Peptide/Peptoid Oligomers

Check out our latest paper Navigating a 1E+60 Chemical Space of Peptide/Peptoid Oligomers in the special issue on Exploration of (Ultra)Big Chemical Spaces in Molecular Informatics Wiley! In this work, we present an update to the Peptide Design Genetic Algorithm (PDGA) and demonstrate its ability to efficiently

Oct 14, 2024 1 min read

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