Reymond Research Group

University of Bern


Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides

The research article Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides was just published in Pharmaceutics.

This study examined 18 transfection peptide dendrimers and demonstrated for the first time the feasibility of peptide dendrimers as highly efficient single component delivery reagents for single strand splice-switching oligonucleotides (ONs). Furthermore, this study showed how siRNA transfection dendrimers DMH13 (named G2,3KL-diPalmitamide(D) in this paper) and DMH18 (named G2,3KL-(Leu)4(D) in this paper) previously reported by Marc Heitz et al. were also the most efficient transfection systems to deliver splice-switching oligonucleotides into cells.

Author(s): Haneen Daralnakhla, Osama Saher, Susanna Zamolo, Safa Bazaz, Jeremy P. Bost, Marc Heitz, Karin E. Lundin, Samir EL Andaloussi, Tamis Darbre, Jean-Louis Reymond, Rula Zain and C. I. Edvard Smith