Sven Bühlmann

Adaptive and mutational responses to peptide dendrimer antimicrobials in Pseudomonas aeruginosa

Adaptive and mutational responses to peptide dendrimer antimicrobials in Pseudomonas aeruginosa

The Article Adaptive and mutational responses to peptide dendrimer antimicrobials in Pseudomonas aeruginosa was published in Antimicrobial Agents and Chemotherapy. Colistin (polymyxin E) is a last resort antibiotic against multidrug-resistant isolates of Pseudomonas aeruginosa. However, the nephro-toxicity of colistin limits its use, spurring the interest in novel antimicrobial peptides (AMP)
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Datasets and their influence on the development of computer assisted synthesis planning tools in the pharmaceutical domain
Publications

Datasets and their influence on the development of computer assisted synthesis planning tools in the pharmaceutical domain

The paper Datasets and their influence on the development of computer assisted synthesis planning tools in the pharmaceutical domain has just been accepted by Chemical Science. Computer Assisted Synthesis Planning (CASP) has gained considerable interest as of late. Herein we investigate a template-based retrosynthetic planning tool, trained on a variety
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X‐Ray Crystal Structure of a Second Generation Peptide Dendrimer in Complex with Pseudomonas aeruginosa Lectin LecB
Publications

X‐Ray Crystal Structure of a Second Generation Peptide Dendrimer in Complex with Pseudomonas aeruginosa Lectin LecB

The paper X‐Ray Crystal Structure of a Second Generation Peptide Dendrimer in Complex with Pseudomonas aeruginosa Lectin LecB has been published by Helvetica Chimica Acta. Dendrimers are regularly branched molecular trees which are notoriously difficult to crystallize. Herein we report the crystal structure of a C‐fucosylated second generation
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Stereoselective pH Responsive Peptide Dendrimers for siRNA Transfection
Publications

Stereoselective pH Responsive Peptide Dendrimers for siRNA Transfection

The paper Stereoselective pH Responsive Peptide Dendrimers for siRNA Transfection has been published by Bioconjugate Chemistry. Transfecting nucleic acids into cells is an essential procedure in biological research usually performed using nonviral transfection reagents. Unfortunately, most transfection reagents have polymeric or undisclosed structures and require nonstandard synthetic procedures. Herein we
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