Check out our latest paper Can Large Language Models Predict Antimicrobial Peptide Activity and Toxicity? in RSC Medicinal Chemistry! Abstract Antimicrobial peptides (AMPs) are naturally occurring or designed peptides up to a few tens of amino acids which may help address the antimicrobial resistance crisis. However, their clinical development is

Check out the latest paper of the von Ballmoos group in collaboration with our group Overcoming Protein Orientation Mismatch Enables Efficient Nanoscale Light-Driven ATP Production in ACS Synthetic Biology! Abstract Adenosine triphosphate (ATP)-producing modules energized by light-driven proton pumps are powerful tools for the bottom-up assembly of artificial cell-like

Check out our latest paper Submonomer synthesis of inverse polyamidoamine (i-PAMAM) dendrimer antibacterials in Helvetica Chimica Acta! Abstract Herein we report that the submonomer method for peptoid synthesis enables access to pure i-PAMAM dendrimers up to 16 amino termini by a divergent solid-phase synthesis using the inexpensive bis(3-trifluoroacetamidopropyl)amine

The Reymond Research Group would like to welcome its new group members: Austia Puckett (Master Student) Robin Knüsel (Master Student) Giulia Baldoni (Ph.D. Student)

The Reymond group wishes you a Merry Christmas and a Happy New Year 2024!

Check out our latest paper Antimicrobial Peptide–Peptoid Hybrids with and without Membrane Disruption in ACS Infectious Diseases! Abstract Among synthetic analogues of antimicrobial peptides (AMPs) under investigation to address antimicrobial resistance, peptoids (N-alkylated oligoglycines) have been reported to act both by membrane disruption and on intracellular targets. Here we

Our paper Alchemical Analysis of FDA Approved Drugs (Markus Orsi, Daniel Probst, Philippe Schwaller and Jean-Louis Reymond, Digital Discovery, 2023,2, 1289-1296, https://doi.org/10.1039/D3DD00039G) has been chosen to be featured on the cover of the October issue of Journal of Digital Discovery. Abstract Chemical space maps

Check out our latest paper Optimizing phosphate couplings for dolichyl diphosphochitobiose to enable protein N-glycosylation studies in HELVETICA! Abstract Herein we report an optimized synthesis for dolichyl diphosphochitobiose (GlcNAc2-PP-Dol25), a probe useful for biochemical and structural studies ofprotein N-glycosylation in eukaryotic cells. We improved three phosphate coupling steps in terms