Reymond Research Group

University of Bern



260. Virtual Exploration of the Ring Systems Chemical Universe Ricardo Visini, Josep Arús-Pous, Mahendra Awale, and Jean-Louis Reymond, J. Chem. Inf. Model., 2017, doi:10.1021/acs.jcim.7b00457

259. Frontiers in Medicinal Chemistry 2017 in Bern, Switzerland Daniel Probst, Marc Heitz, Marion Poirier, Bee Ha Gan, Clémence Delalande, Prof. Dr. Jean-Louis Reymond, ChemMedChem, 2017, doi:10.1002/cmdc.201700306

258. Medicinal and Biological Chemistry (MBC) Library: An Efficient Source of New Hits Víctor Sebastián-Pérez, Carlos Roca, Mahendra Awale, Jean-Louis Reymond, Ana Martinez, Carmen Gil, and Nuria E. Campillo, J. Chem. Inf. Model., 2017, doi:10.1021/acs.jcim.7b00401

257. Design, crystal structure and atomic force microscopy study of thioether ligated D,L-cyclic antimicrobial peptides against multidrug resistant Pseudomonas aeruginosa Runze He, Ivan Dibonaventura, Ricardo Visini, Bee-Ha Gan, Yongchun Fu, Daniel Probst,  Alexandre Luscher, Thilo Kohler, Christian van Delden, Achim Stocker, Wenjing Hong, Tamis Darbre and Jean-Louis Reymond, Chem. Sci., 2017, doi:10.1039/C7SC01599B

256. Chemical Space Guided Discovery of Antimicrobial Bridged Bicyclic Peptides Against Pseudomonas aeruginosa and its Biofilms Ivan Dibonaventura, Xian Jin, Ricardo Visini, Daniel Probst, Sacha Javor, Bee-Ha Gan, Gaelle Michaud, Antonino Natalello, Silvia Maria Doglia, Thilo Kohler, Christian van Delden, Achim Stocker, Tamis Darbre and Jean-Louis Reymond, Chem. Sci., 2017, doi:10.1039/C7SC01314K

255. Chemo-enzymatic synthesis of lipid-linked GlcNAc2Man5 oligosaccharides using recombinant Alg1, Alg2 and Alg11 proteins Ana S Ramírez, Jérémy Boilevin, Chia-Wei Lin, Bee Ha Gan, Daniel Janser, Markus Aebi, Tamis Darbre, Jean-Louis Reymond, Kaspar P Locher, Glycobiology, 2017, doi:10.1093/glycob/cwx045

254. Peptide Dendrimer-Lipid Conjugates as DNA and siRNA Transfection Reagents: Role of Charge Distribution Across Generations Marc Heitz, Albert Kwok, Gabriela A. Eggimann, Florian Hollfelder, Tamis Darbre, and Jean-Louis Reymond, Chimia, 2017, 71(4), 220-225

253. Fragment Database FDB-17 Ricardo Visini, Mahendra Awale and Jean-Louis Reymond, J. Chem. Inf. Model., 2017, 57(4), 700–709

252. WebMolCS: a Web-Based Interface for Visualizing Molecules in 3D Chemical Spaces Mahendra Awale, Daniel Probst and Jean-Louis Reymond, J. Chem. Inf. Model., 2017, 57(4), 643–649

251. The polypharmacology browser: a web-based multi-fingerprint target prediction tool using ChEMBL bioactivity data Mahendra Awale, and Jean-Louis Reymond, J. Cheminform., 2017, 9, 11

250. Characterization of the single-subunit oligosaccharyltransferase STT3A from Trypanosoma brucei using synthetic peptides andlipid-linked oligosaccharide analogs
Ana S. Ramírez Jérémy Boilevin Rasomoy Biswas Bee Ha Gan Daniel Janser Markus Aebi Tamis Darbre Jean-Louis Reymond Kaspar P. Locher, Glycobiology, 2017, 27(6), 525-535

249. Improved fluorescence assays to measure the defects associated with F508del-CFTR allow identification of new active compounds Emily Langron, Michela I. Simone, Clémence M.S. Delalande, Jean-Louis Reymond, David L. Selwood, Paola Vergani, T. Br J Pharmacol, 2017. 174(7), 525-539


248. Efficient Transfection of siRNA by Peptide Dendrimer–Lipid Conjugates Kwok, A., Eggimann, G. A., Heitz, M., Reymond, J.-L., Hollfelder, F. and Darbre, T. ChemBioChem, 2016. 17(23), 2223–2229

247. BIGCHEM: Challenges and Opportunities for Big Data Analysis in Chemistry Igor V. Tetko, Ola Engkvist, Uwe Koch, Jean-Louis Reymond, Hongming Chen Analysis in Chemistry. Mol. Inf., 2016, 35(11-12), 615-621

246. Fluorescent Agonists of the α7 Nicotinic Acetylcholine Receptor Derived from 3-Amino-Quinuclidine Justus J. Bürgi, Sonia Bertrand, Fabrice Marger, Daniel Bertrand, Jean-Louis Reymond Helvetica Chimica Acta, 2016, 99(10), 790–804

245. Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening Falco Kilchmann, Maria J. Marcaida, Sachin Kotak, Thomas Schick, Silvan D. Boss, Mahendra Awale, Pierre Gönczy, and Jean-Louis Reymond J. Med. Chem., 2016, 59(15), 7188-7211

244. Web-based 3D-visualization of the DrugBank chemical space Awale M and Reymond JL, J. Cheminform., 2016, 8, 25.

243. Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages. Abdel-Sayed P, Kaeppli A, Siriwardena T, Darbre T, Perron K, Jafari P, Reymond JL, Pioletti DP, Applegate LA, Sci. Rep., 2016, 6.

242. X-ray structure of a lectin-bound DNA duplex containing an unnatural phenanthrenyl pair. P. Roethlisberger, A. Istrate, M. J. Marcaida Lopez, R. Visini, A. Stocker, J.-L. Reymond and C. J. Leumann, Chem. Commun., 2016, 52(26), 4749-52.

241. Enumeration of Chemical Fragment Space. Book Chapter in Fragment-based Drug Discovery. J.-L. Reymond, R. Visini, M. Awale. Ed. D. A. Erlanson, W. Jahnke, Wiley-VCH, Weinheim, 2016, pp. 57-75.

240. Overcoming antibiotic resistance in Pseudomonas aeruginosa biofilms using glycopeptide dendrimers. G. Michaud, R. Visini, M. Bergmann, G. Salerno, R. Bosco, E. Gillon, B. Richichi, C. Nativi, A. Imberty, A. Stocker, T. Darbre, JL Reymond, Chem. Sci., 2016, 7, 166-182.

239. Multivalency effects on Pseudomonas aeruginosa biofilm inhibition and dispersal by glycopeptide dendrimers targeting lectin LecA. M Bergmann, G Michaud, R Visini, X Jin, E Gillon, A Stocker, A Imberty, T Darbre, JL Reymond, Org. Biomol. Chem., 2016, 14, 138-148.


238. In Vitro Activity of a Novel Antimicrobial Peptide Dendrimer (G3KL) Against Multidrug-Resistant Acinetobacter baumannii and Pseudomonas aeruginosa. J Pires, T N Siriwardena, M Stach, R Tinguely, S Kasraian, F Luzzaro, S L Leib, T Darbre, JL Reymond, A Endimiani, Antimicrob. Agents Chemother., 2015, 59, 7915-7918.

237. PDB-Explorer: a Web-Based Interactive Map of the Protein Data Bank in Shape Space. X Jin, M Awale, M Zasso, D Kostro, L Patiny, JL Reymond, BMC Bioinform., 2015, 16, 339.

236. Optimization of TRPV6 Calcium Channel Inhibitors Using a 3D Ligand-Based Virtual Screening Method. C Simonin, M Awale, Michael Brand, R van Deursen, J Schwartz, M Fine, G Kovacs, P Häfliger, G Gyimesi, A Sithampari, RP Charles, MA Hediger, JL Reymond, Angew. Chem., Int. Ed. Engl., 2015, 54, 14748-14752.

235. Structural Insight into Multivalent Galactoside Binding to Pseudomonas aeruginosa Lectin LecA. Visini R, Jin X, Bergmann M, Michaud G, Pertici F, Fu O, Pukin A, Branson TR, Thies-Weesie DM, Kemmink J, Gillon E, Imberty A, Stocker A, Darbre T, Pieters RJ, Reymond JL, ACS Chem. Biol., 2015, 10, 2455-2462.

234. Structure and mechanism of an active lipid-linked oligosaccharide flippase. Perez C, Gerber S, Boilevin J, Bucher M, Darbre T, Aebi M, Reymond JL, Locher KP, Nature., 2015, 524, 433-438.

233. Similarity Mapplet: Interactive Visualization of the Directory of Useful Decoys and ChEMBL in High Dimensional Chemical Spaces. Awale M, Reymond JL, J. Chem. Inf. Model., 2015, 55, 1509-1516.

232. Bridged bicyclic peptides as potential drug scaffolds: synthesis, structure, protein binding and stability. Bartoloni M, Jin X, Marcaida M, Banha J, Dibonaventura I, Bongoni S, Bartho K, Gräbner O, Sefkow M, Darbre T, Reymond JL, Chem. Sci., 2015, 6, 5473-5490.

231. Trypanosoma brucei Bloodstream Forms Depend upon Uptake of myo-Inositol for Golgi Complex Phosphatidylinositol Synthesis and Normal Cell Growth. Gonzalez-Salgado, A.; Steinmann, M.; Major, L. L.; Sigel, E.; Reymond, J. L.; Smith, T. K.; Butikofer, P., Eukaryot. Cell, 2015, 14, 616-624.

230. Discovery and characterization of a novel non-competitive inhibitor of the divalent metal transporter DMT1/SLC11A2. Montalbetti, N.; Simonin, A.; Simonin, C.; Awale, M.; Reymond, J. L.; Hediger, M. A., Biochem. Pharmacol., 2015, 96, 216-224.

229. Cytotoxic peptide conjugates of dinuclear arene ruthenium trithiolato complexes. Giannini F, Bartoloni M, Paul LE, Süss-Fink G, Reymond JL, Furrer J, Med. Chem. Commun., 2015, 6, 347-350.

228. The chemical space project. Reymond JL, Acc. Chem. Res., 2015, 48, 722-730. This work was featured in:

227. Stereoselective virtual screening of the ZINC database using atom pair 3D-fingerprints. Awale M, Jin X, Reymond JL, J. Cheminform., 2015, 7, 3.


226. The Chemical Space of Flavours. Book Chapter in Foodinformatics, Applications of Chemical Information to Food Chemistry. L. Ruddigkeit, J.-L. Reymond, Ed. K. Martinez-Mayorga, J. L. Medina-Franco, Springer, Heidelberg, 2014, pp. 83-96.

225. Combining Topology and Sequence Design for the Discovery of Potent Antimicrobial Peptide Dendrimers against Multidrug-Resistant Pseudomonas aeruginosa. Stach M, Siriwardena TN, Köhler T, van Delden C, Darbre T, Reymond JL, Angew Chem Int Ed Engl. 2014, 53, 12827-12831.

224. Substrate specificity of cytoplasmic N-glycosyltransferase. Naegeli A, Michaud G, Schubert M, Lin CW, Lizak C, Darbre T, Reymond JL, Aebi M, J Biol Chem. 2014, 289, 24521-24532.

223. Atom Pair 2D-Fingerprints Perceive 3D-Molecular Shape and Pharmacophores for Very Fast Virtual Screening of ZINC and GDB-17. M. Awale, J.-L. Reymond, J. Chem. Inf. Model. 2014, 54, 1892-1907.

222. Expanding the fragrance chemical space for virtual screening. L. Ruddigkeit, M. Awale, J.-L. Reymond, J. Cheminform. 2014, 6, 27.

221. Designed Cell Penetration Peptide Dendrimers Efficiently Internalize Cargo Into Cells. G. A. Eggimann, E. Blattes, S. Buschor, R. Biswas, S. M. Kammer, T. Darbre, J.-L. Reymond, Chem. Commun. 2014, 50, 7254-7257.

220. Discovery of Potent Positive Allosteric Modulators of the α3β2 Nicotinic Acetylcholine Receptor by a Chemical Space Walk in ChEMBL. J. Bürgi, M. Awale, S. Boss, T. Schaer, F. Marger, J. Viveros-Paredes, S. Bertrand, J. Gertsch, D. Bertrand, J.-L. Reymond, ACS Chem. Neurosci. 2014, 5, 346-359.

219. A multi-fingerprint browser for the ZINC database. M. Awale, J.-L. Reymond, Nucleic Acids Res. 2014, 42, 234-239.

218. OMA & OPA - A Software Tool for Mass Spectrometric Sequencing of Nucleic Acids. Y. Hari, S. R. Stücki, A. Nyakas, L. Blum, J.-L. Reymond, S. Schürch, Chimia, 2014, 68, 86.

217. Stereoselective synthesis and structure determination of bicyclo[3.3.2]decapeptide. M. Bartoloni, S. Waltersperger, M. Bumann, A. Stocker, T. Darbre and J.-L. Reymond, Arkivoc, 2014, iii, 113-123.

216. A Tribute to Pierre Vogel. R. Neier and J.-L. Reymond, Arkivoc, 2014, iii, 1-5 (editorial).

215. Considerations on the Drug-Like Chemical Space. Book Chapter in Computational Chemogenomics, J.-L. Reymond, L. Ruddigkeit, M. Awale, Ed. E. Jacoby, Pan Standford Publishing, Singapore, 2014, pp. 39-64.

214. A "Social" Network of Isomers based on Bond Count Distance: Algorithms. T. Kouri, M. Awale, J. Slyby, J.-L. Reymond, D. Mehta, J. Chem. Inf. Model. 2014, 54, 57-68.

213. A catalytically essential motif in the external loop 5 of the bacterial oligosaccharyltransferase PglB. C. Lizak, S. Gerber, D. Zinne , G. Michaud, M. Schubert, F. Chen, M. Bucher, T. Darbre, R. Zenobi, J.-L. Reymond , K. P. Locher, J. Biol. Chem. 2014, 289, 735-746.


212. Expanding the Topological Space of Bioactive Peptides. J.-L. Reymond, T. Darbre, Chimia 2013, 67, 864-867.

211. Unexpected reactivity and mechanism of carboxamide activation in bacterial N-linked protein glycosylation. C. Lizak, S. Gerber, G. Michaud, M. Schubert, Y. Y. Fan, M. Bucher, T. Darbre, M. Aebi, J.-L. Reymond, K. P. Locher, Nat. Commun. 2013, 4, 2627.

210. Structure-Based Optimization of the Terminal Tripeptide in Glycopeptide Dendrimer Inhibitors of Pseudomonas aeruginosa Biofilms Targeting LecA. R. U. Kadam, M. Bergmann, D. Garg, G. Gabrieli, A. Stocker, T. Darbre, J.-L. Reymond, Chem. Eur. J. 2013, 18, 17054-17063.

209. Electrostatics and flexibility drive membrane recognition and early penetration by the antimicrobial peptide dendrimer bH1. H. K. Ravi, M. Stach, T. A. Soares, T. Darbre, J.-L. Reymond, M. Cascella, Chem. Commun. 2013, 49, 8821-8823.

208. CH-π "T-Shape" Interaction with Histidine Explains Binding of Aromatic Galactosides to Pseudomonas aeruginosa lectin LecA. R. U. Kadam, D. Garg J. Schwartz, R. Visini, M. Sattler, A. Stocker, T. Darbre, J.-L. Reymond, ACS Chem. Biol. 2013, 8, 1925-1930.

207. Convergent synthesis and cellular uptake of multivalent cell penetrating peptides derived from Tat, Antp, pVEC, TP10 and SAP. G. A. Eggimann, S. Buschor, T. Darbre and J.-L. Reymond, Org. Biomol. Chem. 2013, 11, 6717-6733.

206. The SMIfp (SMILES fingerprint) Chemical Space for Virtual Screening and Visualization of Large Databases of Organic Molecules. J. Schwartz J, M. Awale and J.-L. Reymond, J. Chem. Inf. Model. 2013, 53, 1979-1989.

205. Peptide Dendrimer/Lipid Hybrid Systems are Efficient DNA Transfection Reagents: Structure-Activity Relationships Highlight the Role of Charge Distribution Across Dendrimer Generations. A. Kwok, Albert, G. Eggimann, J.-L. Reymond, T. Darbre, F. Hollfelder, ACS Nano. 2013, 7, 4668-4682.

204. Fluorescence-Based Assay for the Optimization of the Activity of Artificial Transfer Hydrogenase within a Biocompatible Compartment. T. Heinisch, K. Langowska, P. Tanner, J.-L. Reymond, W. Meier, C. Palivan, T. R. Ward, ChemCatChem. 2013, 5, 720-723.

203. Mechanism of bacterial oligosaccharyltransferase: in vitro quantification of sequon binding and catalysis. S. Gerber, C. Lizak, G. Michaud, M. Bucher, T. Darbre, M. Aebi, J.-L. Reymond, K. P. Locher, J. Biol. Chem. 2013, 288, 8849-8861.

202. Glycopeptide dendrimers as Pseudomonas aeruginosa biofilm inhibitors. J.-L. Reymond, M. Bergmann, T. Darbre, Chem. Soc. Rev. 2013, 42, 4814-4822.

201. The MQN-Mapplet: Visualization of Chemical Space with Interactive Maps of DrugBank, ChEMBL, PubChem, GDB-11 and GDB-13. M. Awale, R. van Deursen, J.-L. Reymond, J. Chem. Inf. Model. 2013, 53, 509-518.

200. Visualization and Virtual Screening of the Chemical Universe Database GDB-17. L. Ruddigkeit, L. C. Blum, J.-L. Reymond, J. Chem. Inf. Model. 2013, 53, 56-65.

199. OMA and OPA-Software-Supported Mass Spectra Analysis of Native and Modified Nucleic Acids. Nyakas, L. C. Blum, S. R. Stucki, J.-L. Reymond, S. Schurch, J. Am. Soc. Mass. Spectrom. 2013, 24, 249-256.

198. Multivalent glycoconjugates as anti-pathogenic agents. A. Bernardi, J. Jimenez-Barbero, A. Casnati, C. De Castro, T. Darbre, F. Fieschi, J. Finne, H. Funken, K. E. Jaeger, M. Lahmann, T. K. Lindhorst, M. Marradi, P. Messner, A. Molinaro, P. V. Murphy, C. Nativi, S. Oscarson, S. Penades, F. Peri, R. J. Pieters, O. Renaudet, J.-L. Reymond, B. Richichi, J. Rojo, F. Sansone, C. Schaffer, W. B. Turnbull, T. Velasco-Torrijos, S. Vidal, S. Vincent, T. Wennekes, H. Zuilhof, A. Imberty, Chem. Soc. Rev. 2013, 42, 4709-4727.

197. pH-tuned metal coordination and peroxidase activity of a peptide dendrimer enzyme model with a Fe(ii)bipyridine at its core. P. Geotti-Bianchini, T. Darbre, J.-L. Reymond, Org. Biomol. Chem., 2013, 11, 344-352.


196. Screening Methods for Enzymes. J.-L. Reymond, Book Chapter in Comprehensive Chirality, Ed. E. M. Carreira, H. Yamamoto, Eds. Elsevier, Amsterdam, 2012, pp. 6-20.

195. Enumeration of 166 billion organic small molecules in the chemical universe database GDB-17. L. Ruddigkeit, R. van Deursen, L. C. Blum and J.-L. Reymond, J. Chem. Inf. Model., 2012, 52, 2864-2875.

194. Synthesis and Nicotinic Receptor Activity of Chemical Space Analogs of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711). L. Bréthous, N. Garcia-Delgado, J. Schwartz, S. Bertrand, D. Bertrand and J.-L. Reymond, J. Med. Chem., 2012, 55, 4605-4618.

193. Exploring chemical space for drug discovery using the chemical universe database. J.-L. Reymond and M. Awale, ACS Chem. Neurosci., 2012, 3, 649-657.

192. The enumeration of chemical space. J.-L. Reymond, L. Ruddigkeit, L. Blum, R. van Deursen, WIREs Comput. Mol. Sci. 2012, 2, 717-733.

191. Cluster analysis of the DrugBank chemical space using molecular quantum numbers. M. Awale and J.-L. Reymond, Bioorg. Med. Chem. 2012, 18, 5372-5378.

190. Peptide and glycopeptide dendrimer apple trees as enzyme models and for biomedical applications. T. Darbre and J.-L. Reymond, Org. Biomol. Chem. 2012, 10, 1483-1492.

189. Membrane disrupting antimicrobial peptide dendrimers with multiple amino termini. M. Stach, N. Maillard, R. U. Kadam, D. Kalbermatter, M. Meury, M. G. P. Page, D. Fotiadis, T. Darbre and J.-L. Reymond, MedChemComm. 2012, 3, 86-89.


188. Exploring the chemical space of known and unknown organic small molecules at L. C. Blum, R. van Deursen, and J.-L. Reymond, Chimia 2011, 65, 863-867.

187. Discovery of a7-Nicotinic Receptor Ligands by Virtual Screening of the Chemical Universe Database GDB-13. L. C. Blum, R. van Deursen, S. Bertrand, M. Mayer, J. J. Bürgi, D. Bertrand, and J.-L. Reymond, J. Chem. Inf. Model. 2011, 51 3105-3112.

186. Expanding the accessible chemical space by solid phase synthesis of bicyclic homodetic peptides. M. Bartoloni, R. U. Kadam, J. Schwartz, J. Furrer, T. Darbre, J.-L. Reymond, Chem. Commun. 2011, 47, 12634-12636.

185. Combinatorial Libraries of Dendritic Glycoclusters.Book Chapter in Synthesis and Biological Applications of Glycoconjugates. J.-L. Reymond, T. Darbre,. Ed. O. Renaudet and N. Spinelli, Bentham e-books 2011, pp. 116-128.

184. Peptide Dendrimers as Artificial Proteins. Book chapter in Designing Dendrimers, T. Darbre, J.-L. Reymond, Ed. S. Campagna, P. Ceroni, F Puntoriero, JohnWiley&Sons 2011, pp. 505-528.

183. A Glycopeptide dendrimer inhibitor of the Galactose Specific Lectin LecA and of Pseudomonas aeruginosa Biofilms. R. U. Kadam, M. Bergmann, M. Hurley, D. Garg, M. Cacciarini, M. A. Swiderska, C. Nativi, M. Sattler, A. R. Smyth, P. Williams, M. Cámara, A. Stocker, T. Darbre, J.-L. Reymond, Angew. Chem. Int. Ed. 2011, 50, 10631-10635.

182. Peptide dendrimer enzyme models for ester hydrolysis and aldolization prepared by convergent thioether ligation. N. A. Uhlich, T. Darbre, J.-L. Reymond, Org. Biomol. Chem. 2011, 9, 7071-7084.

181. What we have learned from crystal structures of proteins to receptor function. J.-L. Reymond, R. van Deursen, D. Bertrand, Biochem. Pharmacol. 2011, 82, 1521-1527.

180. Visualisation and subsets of the chemical universe database GDB-13 for virtual screening. L. C. Blum, R. van Deursen, J.-L. Reymond, J. Comput. Aided Mol. Des. 2011, 25, 637-647.

179. Visualisation of the chemical space of fragments, lead-like and drug-like molecules in PubChem. R. van Deursen, L. C. Blum, J.-L. Reymond, J. Comput. Aided Mol. Des. 2011, 25, 649-662.

178. Structural and functional analyses reveal that Staphylococcus aureus antibiotic resistance factor HMRA is a zinc-dependent endopeptidase. T. O. Botelho, T. Guevara, A. Marrero, P. Arêde, V. S. Fluxa J.-L. Reymond, D. C. Oliveira, F. X. Gomis-Rüth, J. Biol. Chem. 2011, 286, 25697-25709.

177. Synthesis of glycopeptide dendrimers, dimerization and affinity for Concanavalin. A. R. Euzen, J.-L. Reymond, Bioorg. Med. Chem. 2011, 19, 2879-2887.

176. Combinatorial Discovery of Peptide Dendrimer Enzyme Models Hydrolyzing Isobutyryl Fluorescein. N. Maillard, R. Biswas, T. Darbre, J.-L. Reymond, ACS Comb. Sci. 2011, 13, 310-320.

175. Inhibition of Pseudomonas aeruginosa biofilms with a glycopeptide dendrimer containing D-amino acids. E. M. V. Johansson, R. U. Kadam, G. Rispoli, S. A. Crusz, K. M. Bartels, S. P. Diggle, M. Cámara, P.Williams, K. E. Jaeger, T. Darbre, J.-L. Reymond, Med. Chem. Commun. 2011, 2, 418-420.

174. Five-Substrate Cocktail as a Sensor Array for Measuring Enzyme Activity Fingerprints of Lipases and Esterases. N. Maillard, P. Babiak, S. Syed, R.Biswas, L. Mandrich, G. Manco, J.-L. Reymond, Anal. Chem. 2011, 83, 1437-1442.

173. Bead Diffusion Assay for Discovering Antimicrobial Cyclic Peptides. V. S. Fluxa, N. Maillard, M. G. P. Page , J.-L. Reymond, Chem. Commun. 2011, 47 1434-1436.

172. Glycopeptide dendrimers: tuning carbohydrate-lectin interactions with amino acids. R. Euzen, J.-L. Reymond, Mol. Biosys. 2011, 7, 411-421.


171. A Searchable Map of Pubchem. R. van Deursen, L. C. Blum, J.-L. Reymond, J. Chem. Inf. Model. 2010, 50 1924-1934.

170. Comparing dendritic with linear esterase peptides by screening SPOT arrays for catalysis. R. Biswas, N. Maillard, J. Kofoed, J.-L. Reymond, Chem. Commun. 2010 , 8746-8748.

169. Identification of Selective Norbornane-Type Aspartate Analogue Inhibitors of the Glutamate Transporter 1 (GLT-1) from the Chemical Universe Generated Database (GDB). E. Luethi, K. T. Nguyen, M. Bürzle, L.C. Blum, Y. Suzuki, M. Hediger, J.-L. Reymond J. Med. Chem. 2010, 53, 7236-7250.

168. Glycopeptide dendrimer colchicine conjugates targeting cancer cells. E. M.V. Johansson, J. Dubois, T. Darbre, J,-L. Reymond, Bioorg. Med. Chem. 2010, 18, 6589-6597.

167. Exploring a7-Nicotinic Receptor Ligand Diversity by Scaffold Enumeration from the Chemical Universe Database GDB. N. Garcia-Delgado, S. Bertrand, K. T. Nguyen, R. van Deursen, D.Bertrand, J.-L. Reymond, ACS Med. Chem. Lett. 2010, 1, 422-426.

166. Chemical Space as a source for new drugs. J.-L. Reymond, R. van Deursen, L. C. Blum, Lars Ruddigkeit, Med. Chem. Commun. 2010, 1, 30-38.

165. Selected papers from the Biotrans 2009 Conference (Editorial). J.-L. Reymond, J. Mol. Cat. B: Enzymatic 2010, 65, 1-2.

164. Future turnovers in enzyme catalysis (Editorial). J.-L. Reymond, R. A. Sheldon, Curr. Opin. Chem. Biol. 2010, 14, 113-4.

163. Structure and Binding of Peptide-Dendrimer Ligands to Vitamin B12. N. A. Uhlich, A. Natalello, R. U. Kadam, S. M. Doglia, J.-L. Reymond, T. Darbre, Chembiochem 2010, 11, 358-65.


162. A dendritic signal amplifier (commentary). M. Swiderska, J.-L. Reymond, Nature Chemistry 2009, 1, 527-528.

161. Classification of Organic Molecules by Molecular Quantum Numbers. K. T. Nguyen, L. C. Blum, R. van Deursen, J.-L. Reymond, ChemMedChem 2009, 4, 1803-1805.

160. Remote Control of Bipyridine-Metal Coordination within a Peptide Dendrimer. N. A. Uhlich, P. Sommer, C. Bühr, S. Schürch, J.-L. Reymond, T. Darbre, Chem. Commun. 2009, 6237-6239.

159. Structure-Activity Relationship Studies in Single-Site Esterase Peptide Dendrimers. Sacha Javor, J.-L. Reymond, Isr. J. Chem. 2009, 49, 129-136.

158. 970 Million Drug-like Small Molecules for Virtual Screening in the Chemical Universe Database GDB-13. L. C. Blum, J.-L. Reymond, J. Am. Chem. Soc. 2009, 131, 8732-8733.

157. Proteolysis of Peptide Dendrimers. P. Sommer , V. S. Fluxa, T. Darbre, J.-L. Reymond, Chembiochem 2009, 10, 1527-1536.

156. Phenolic oxime oligomers inhibit Alzheimer's amyloid fibril formation and disaggregate fibrils in vitro. G. T. Dolphin, O. Renaudet, M. Ouberai, P. Dumy, J. Garcia, J.-L. Reymond, Chembiochem 2009, 10, 1325-1329.

155. Identification of Catalytic Peptide Dendrimers by "Off-Bead" in Silica High-Throughput Screening of Combinatorial Libraries. N. Maillard, T. Darbre, J.-L. Reymond, J. Comb. Chem. 2009, 11, 667-675.

154. 3-(Aminomethyl)piperazine-2,5-dione as a novel NMDA glycine site inhibitor from the chemical universe database GDB. K. T. Nguyen, E. Luethi, S. Syed, S. Urwyler, S. Bertrand, D. Bertrand, J.-L. Reymond, Bioorg. Med. Chem. Lett. 2009, 19, 3832-2835.

153. [Molecular dynamics and docking studies of single site esterase peptide dendrimers.]
( S. Javor, J.-L. Reymond, J. Org. Chem. 2009, 74, 3665-3674.

152. Exploration of Chemical Space for Drug Discovery by Database Generation. J.-L. Reymond, K. T. Nguyen, Chemistry Today 2009, 27, no. 2, pp 37-40.

151. Fluorescence Assays for Biotransformations. J.-L. Reymond. Book chapter in Modern Biocatalysis, Ed. W.-D. Fessner and T. Anthonsen, Wiley-VCH, Weinheim 2009, pp. 1-16.

150. Glycopeptide dendrimers with high affinity for the fucose binding lectin PA-IIL from Pseudomonas aeruginosa. E. Kolomiets, M. A. Swiderska, R. U. Kadam, E. M. V. Johansson, K.-E. Jaeger, Tamis Darbre, J.-L. Reymond, ChemMedChem 2009, 4, 562-569.

149. Combinatorial Libraries of Peptide Dendrimers: Design, Synthesis, On-Bead High-Throughput Screening, Bead Decoding and Characterization. N. Maillard, A. Clouet, T. Darbre, J.-L. Reymond, Nature Protoc. 2009, 4, 132-142.

148. Enzyme Assays. J.-L. Reymond, V. S. Fluxa N. Maillard, Chem. Commun. 2009, 34-46.

147. On-bead cyclization in a combinatorial library of 15,625 octapeptides. V. S. Fluxa, J.-L. Reymond, Bioorg. Med. Chem. 2009, 17, 1018-1025.


146. α-Helix Stabilization within a Peptide Dendrimer. S. Javor, A. Natalello, S.M. Doglia, J.-L. Reymond, J. Am. Chem. Soc. 2008, 130, 17248-17249.

145. Inhibition and Dispersion of Pseudomonas aeruginosa Biofilms by Glycopeptide Dendrimers Targeting the Fucose-Specific Lectin LecB. E. M. V. Johansson , S. A. Crusz, E. Kolomiets, L. Buts, R. U. Kadam, M. Cacciarini, K.-M. Bartels, S. P. Diggle, M. Cámara, P. Williams, R. Loris, C. Nativi, F. Rosenau, K.-E. Jaeger, T. Darbre, J.-L. Reymond, Chem. Biol. 2008, 15, 1249-1257.

144. Colorimetric and Fluorescence-Based Screening. Book chapter in Protein Engineering Handbook, Ed. S. Lutz, U.T. Bornscheuner, Wiley-VCH, Weinheim 2008, pp. 669-711.

143. A cyclodecapeptide ligand to vitamin B12. V. Duléry, N. A. Uhlich, N. Maillard, V. S. Fluxa J. Garcia, P. Dumy, O. Renaudet, J.-L. Reymond, T. Darbre, Org. Biomol. Chem. 2008, 6, 4134-4141.

142. Glycopeptide dendrimers for biomedical applications. T. Darbre, J.-L. Reymond, Curr. Top. Med. Chem 2008, 8, 1286-1293.

141. Discovery of NMDA Glycine Site Inhibitors from the Chemical Universe Database GDB. K. T. Nguyen, S. Syed, S. Urwyler, S. Bertrand, D. Bertrand, J.-L. Reymond, ChemMedChem 2008, 3, 1520-1524.

140. Enzyme assay and activity fingerprinting of hydrolases with the red-chromogenic adrenaline test. V. S. Fluxa D. Wahler, J.-L. Reymond, Nature Protoc. 2008, 3, 1270-1277.

139. The Search for New Enzymes. J.-L. Reymond, W. Streit, Book Chapter in Organic Synthesis with Enzymes , Ed. V. Gotor, I. Alfonso and E. Garcia-Urdiales, Wiley-VCH, Weinheim, 2008, 65-86.

138. A Peptide Dendrimer Model for Vitamin B(12) Transport Proteins. P. Sommer, N. Uhlich, J.-L. Reymond, T. Darbre, Chembiochem 2008, 9, 689-693.

137. Substrate Arrays for Fluorescence-Based Enzyme Fingerprinting and High-Throughput Screening. J.-L. Reymond, Ann. N. Y. Acad. Sci. 2008, 1130, 12-20.


136. Activity of ulilysin, an archaeal PAPP-A-related gelatinase and IGFBP protease. C. Tallant, R. Garcia-Castellanos, A. Marrero, F. Canals, Y. Yang, J.-L. Reymond, M. Sola, U. Baumann, F. X. Gomis-Ruth.Biol. Chem. 2007, 388, 1243-1253.

135. Identification of protease substrates by combinatorial profiling on tentagel beads. J. Kofoed and J.-L. Reymond. Chem. Commun. 2007, 48, 4453-4455.

134. A General Method for Designing Combinatorial Peptide Libraries Decodable by Amino Acid Analysis. J. Kofoed, J.-L. Reymond, J. Comb. Chem. 2007, 9, 1046-1052.

133. A Peptide Dendrimer Enzyme Model with a Single Catalytic Site at the Core. S. Javor, E. Delort, T. Darbre, J.-L. Reymond, J. Am. Chem. Soc. 2007, 129, 13238-13246.

132. STM-Visualization of Thiol-Containing Peptide Dendrimers on Au(111). E. Delort, E. Szöcs, R. Widmer, H. Siegenthaler, J.-L. Reymond. Macromol. Bioscience 2007, 7, 1024-1031.

131. A Peptide Dendrimer Approach to Artificial Enzymes. T. Darbre, J.-L. Reymond Chemistry Today 2007, 25, 25-27.

130. Combinatorial Variation of Branching Length and Multivalency in a Large (390,625 Member) Glycopeptide Dendrimer Library: Ligands for Fucose-specific Lectins. E. M. V. Johansson, E. Kolomiets, F. Rosenau, K.-E. Jaeger, T. Darbre, J.-L. Reymond, New J. Chem. 2007, 31, 1291-1299.

129. Neoglycopeptide Dendrimer Libraries as a Source of Lectin Binding Ligands. E. Kolomiets, E. M. V. Johansson, O. Renaudet, T. Darbre, J.-L. Reymond, Org. Lett. 2007, 9, 1465-1468.

128. Chemical Space Travel. R. van Deursen, J.-L. Reymond, ChemMedChem 2007, 2, 636-640.

127. Virtual exploration of the chemical universe up to 11 atoms of C, N, O, F: assembly of 26.4 million structures (110.9 million stereoisomers) and analysis for new ring systems, stereochemistry, physico-chemical properties, compound classes and drug discovery. T. Fink, J.-L. Reymond, J. Chem. Inf. Model. 2007, 47, 342-353.

126. Fluorogenic Substrates for Lipases, Esterases and Acylases Using a TIM-Mechanism for Signal Release. R. Sicart, M.-P. Collin, J.-L. Reymond, Biotechnol. J. 2007, 2, 221-231.

125. Screening Systems. J.-L. Reymond, P. Babiak, Adv. Biochem. Eng. Biotechnol.2007, 105, 31-58.


124. Peptide Dendrimers as Artificial Enzymes, Receptors, and Drug-Delivery Agents. T. Darbre, J.-L.  Reymond, Acc. Chem. Res. 2006, 39, 925-934.

123. Artificial aldolases from peptide dendrimer combinatorial libraries. J. Kofoed, T. Darbre, J.-L. Reymond, Org. Biomol. Chem. 2006, 3268-3281.

122. A red-fluorescent substrate microarray for lipase fingerprinting. J. Grognux,  J.-L. Reymond, Mol. Biosys. 2006, 2, 492-498.

121. Synthesis and Activity of Histidine Containing Catalytic Peptide Dendrimers. E. Delort, N.-Q. Nguyen-Trung, T. Darbre and J.-L. Reymond, J. Org. Chem. 2006, 71, 4468-4480.

120. Isolation and biochemical characterization of two novel metagenome-derived esterases. C. Elend, C. Schmeisser, C. Leggewie, P. Babiak, J. D. Carballeira, H. L. Steele, J.-L. Reymond, K.-E. Jaeger, W. R. Streit, Appl. Environ. Microbiol. 2006, 72, 3637-45.

119. Low background FRET- substrates for lipases and esterases suitable for high-throughput screening under basic (pH 11) conditions. Y. Yang, P. Babiak, J.-L. Reymond, Org. Biomol. Chem. 2006, 4, 1746-1754.

118. Dual Mechanism of Zinc-Proline Catalyzed Aldol Reactions in Water. J. Kofoed, T. Darbre, J.-L. Reymond, Chem. Commun. 2006, 1482-1484.

117. New Monofunctionalized Fluorescein Derivatives for the Efficient High-Throughput Screening of Lipases and Esterases in Aqueous Media. Y. Yang, P. Babiak, J.-L. Reymond, Helv. Chim. Acta 2006, 89, 404-415.

116. Fingerprinting Methods for Hydrolases. Book Chapter in Enzyme Assays, Ed. J.-L. Reymond, Wiley-VCH, Weinheim 2006, pp. 271-302.

115. Combinatorial Synthesis, Selection and Properties of Esterase Peptide Dendrimers. A. Clouet, T. Darbre, J.-L. Reymond, Biopolymers 2006, 84,114-123.


114. Screening Methods for Catalytic Antibodies. Book chapter in Catalytic Antibodies, Ed. E. Keinan, Wiley-VCH, Weinheim,2005,pp. 217-242.

113. Dendrimers as artificial enzymes. J. Kofoed, J.-L. Reymond,Curr. Opin. Chem. Biol. 2005, 9, 656-664.

112. A fluorescence-based assay for Baeyer-Villiger monooxygenases, hydroxylases and lactonases. R. Sicard, L. S. Chen, A. J. Marsaioli, J.-L. Reymond, Adv. Synth. Catal. 2005,347, 1041-1050 .

111. Multienzyme Profiling of Thermophilic Microorganisms with a Substrate Cocktail Assay. R. Sicard, J.-P. Goddard, M. Mazel, C. Audiffrin, L. Fourage, G. Ravot, D. Wahler, F. Lefèvre, J.-L. Reymond, Adv. Synth. Catal. 2005, 347, 987-996 .

110. Prebiotic carbohydrate synthesis: zinc proline catalyzes direct aqueous aldol reactions of α-hydroxy aldehydes and ketones. J. Kofoed, J.-L. Reymond, T. Darbre, Org. Biomol. Chem. 2005, 3, 1850-1855 .

109. Protease Profiling Using a Fluorescent Domino Peptide Cocktail. Y. Yongzheng, J.-L. Reymond, Mol. Biosys. 2005, 1, 57-63 .

108. Synthetic diversity and catalytic mechanism of peptide dendrimers. E. Delort, T. Darbre, J.-L. Reymond, Chimia 2005, 59, 77-80.

107. Inhibition of Mitosis by Glycopeptide Dendrimer Conjugates of Colchicine. D. Lagnoux, T. Darbre, M. L. Schmitz, J.-L. Reymond, Chem. Eur. J. 2005, 11, 3941-3950.

106. Virtual Exploration of the Small Molecule Chemical Universe below 160 Daltons. T. Fink, H. Bruggesser, J.-L. Reymond, Angew. Chem. Int. Ed. 2005, 44, 1504-1508.

105. Mechanistic study of proton transfer and hysteresis in catalytic antibody 16E7 by site-directed mutagenesis and homology modelling. L. Zheng, R. Manetsch, W.-D. Woggon, U. Baumann, J.-L. Reymond, Bioorg. Med. Chem. 2005, 13, 1021-1029.

104. A High-Throughput, Low Volume Enzyme Assay on Solid Support. P. Babiak, J.-L. Reymond, Anal. Chem. 2005, 77, 373-377.


103. Studies on whole cell fluorescence-based screening for epoxide hydrolases and Baeyer-Villiger monooxygenases. B. Bicalho, L. S. Chen, J. Grognux, J.-L. Reymond, A. J. Marsaioli, J. Braz. Chem. Soc. 2004, 15, 911-916.

102. Spectrophotometric Enzyme Assays for High-throughput Screening. J.-L. Reymond, Food Technol. Biotechnol. 2004, 42, 265-269.

101. A Strong Positive Dendritic Effect in a Peptide Dendrimer-Catalyzed Ester Hydrolysis Reaction. E. Delort, T. Darbre, J.-L. Reymond, J. Am. Chem. Soc. 2004, 126, 15642-15643.

100. Outrunning the Bear. J.-L. Reymond, Angew. Chem. Int. Ed. 2004, 43, 5577-5579.

99. New C(4)-Functionalized Colchicine Derivatives by a Versatile Multicomponent Electrophilic Aromatic Substitution. N. Bensel, D. Lagnoux, V. Niggli, M. Wartmann, J.-L. Reymond, Helv. Chim. Acta 2004, 87, 2266-2272.

98. Esterolytic Peptide Dendrimers with a Hydrophobic Core and Catalytic Residues at the Surface. A. Clouet, T. Darbre, J.-L. Reymond, Adv. Synth. Catal. 2004, 346, 1195-1204.

97. Universal chromogenic substrates for lipases and esterases. J. Grognux, D. Wahler, E. Nyfeler, J.-L. Reymond, Tetrahedron Asym. 2004, 15, 2981-2989.

96. An Efficient One-Step Site-Directed and Site-Saturation Mutagenesis Protocol. L. Zheng, U. Baumann, J.-L. Reymond, Nucleic Acids Research Methods Online 2004, 32, e115.

95. Enzyme Fingerprinting with Substrate Cocktails. J.-P. Goddard, J.-L. Reymond, J. Am. Chem. Soc. 2004, 126, 11116-11117.

94. A Combinatorial Approach to Catalytic Peptide Dendrimers. A. Clouet, T. Darbre, J.-L. Reymond, Angew. Chem. Int. Ed. 2004, 43, 4612-4615.

93. Expression Improvement and Mechanistic Study of the Retro-Diels-Alderase Catalytic Antibody 10F11 by Site-directed Mutagenesis. L. Zheng, J.-P. Goddard, U. Baumann, J.-L. Reymond, J. Mol. Biol. 2004, 341, 807-814.

92. Enzyme assays for high-throughput screening. J.-P. Goddard, J.-L. Reymond, Curr. Opin. Biotechnol. 2004, 15, 314-322.

91. Zinc–proline catalyzed pathway for the formation of sugars. J. Kofoed , M. Machuqueiro, J.-L. Reymond, T. Darbre, Chem. Commun. 2004, 1540-1541.

90. Selective Catalysis with Peptide Dendrimers. C. Douat-Casassus, T. Darbre, J.-L. Reymond, J. Am. Chem. Soc. 2004, 126, 7817-7826.

89. Recent advances in enzyme assays. J.-P. Goddard, J.-L. Reymond., Trend Biotechnol. 2004, 22, 363-370.

88. Classifying Enzymes from Selectivity Fingerprints. J. Grognux, J.-L. Reymond, ChemBioChem 2004, 5, 826-831.

87. Theoretical Investigation of the Origins of Catalysis of a Retro-Diels-Alder Reaction by Antibody 10F11. A. G. Leach, K. N. Houk, J.-L. Reymond, J. Org. Chem. 2004,69, 3683-3692.

86. Fluorescence Assay and Screening of Epoxide Opening by Nucleophiles. F. Badalassi, G. Klein, P. Crotti, J.-L. Reymond, Eur. J. Org. Chem. 2004, 2557-2566.

85. Aldehyde detection by chromogenic/fluorogenic oxime bond fragmentation. S. Salahuddin, O. Renaudet, J.-L. Reymond, Org. Biomol. Chem. 2004, 2, 1471-1475.

84. A Catalytic Antibody against a Tocopherol Cyclase Inhibitor. R. Manetsch, L. Zheng, M. T. Reymond, W.-D. Woggon, J.-L. Reymond, Chem. Eur. J. 2004, 10, 2487-2506.

83. Structure activity relationships in aminocyclopentitol glycosidase inhibitors. L. Gartenmann Dickson, E. Leroy, J.-L. Reymond, Org. Biomol. Chem. 2004, 2, 1217-1226.

82. Molecular Mechanism of Enantioselective Proton Transfer to Carbon in Catalytic Antibody 14D9. L. Zheng, U. Baumann, J.-L. Reymond, Proc. Natl. Acad. Sci. U. S. A. 2004, 101, 3387-3392.

81. Synthesis and Esterolytic Activity of Catalytic Peptide Dendrimers. D. Lagnoux, E. Delort, C. Douat-Casassus, A. Esposito, J.-L. Reymond, Chem. Eur. J. 2004, 10, 1215-1226.

80. Synthesis of Ether Oligomers. O. Renaudet, J.-L. Reymond, Org. Lett. 2004, 6, 397-400.

79. Adrenaline Profiling of Lipases and Esterases with 1,2-Diol and Carbohydrate Acetates. D. Wahler, O. Boujard, F. Lefèvre, J.-L. Reymond, Tetrahedron 2004, 60, 703-710.


78. Iterative Oxime Bond Chemistry Leads to Protease Inhibitors. O. Renaudet, J.-L. Reymond, Org. Lett. 2003, 5, 4693-4696.

77. Fluorogenic Cyanohydrin Esters as Chiral Probes for Esterase and Lipase Activity. E. Leroy, N. Bensel, J.-L. Reymond, Adv. Syn. Catal. 2003, 345, 859-865.

76. b-Aminoalcohol properfumes. Y. Yang, D. Wahler, J.-L. Reymond, Helv. Chim. Acta 2003, 86, 2928-2936.

75. A sensitive and selective high-throughput screening fluorescence assay for lipases and esterases. E. Nyfeler, J. Grognux, D. Wahler, J.-L. Reymond, Helv. Chim. Acta2003, 86, 2919-2927.

74. Synthesis and Evaluation of Chromogenic and Fluorogenic Analogs of Glycerol for Enzyme Assays. E. M. Gonzalez-Garcia, J. Grognux, D. Wahler, J.-L. Reymond, Helv. Chim. Acta 2003, 86, 2458-2470.

73. A green fluorescent chemosensor for amino acids provides a versatile high-throughput screening (HTS) assay for proteases. K. E. S. Dean, G. Klein, O. Renaudet and J.-L. Reymond, Bioorg. Med. Chem. Lett. 2003, 10, 1653-1656.

72. A low background high-Throughput screening (HTS) fluorescence assay for lipases and esterases using acyloxymethylethers of umbelliferone. E. Leroy, N. Bensel and J.-L. Reymond. Bioorg. Med. Chem. Lett. 2003, 13, 2105-2108.

71. Discovery of New Peptide-based Catalysts for the Direct Asymmetric Aldol Reaction. J. Kofoed, J. Nielsen, J.-L. Reymond, Bioorg. Med. Chem. Lett. 2003, 15, 2445-2447.

70. Production of a Functional Catalytic Antibody ScFv-NusA Fusion Protein in the Bacterial Cytoplasm. L. Zheng, U. Baumann, J.-L. Reymond, J. Biochem 2003, 5, 577?81.

69. Catalytic Peptide Dendrimers. A. Esposito, E. Delort, D. Lagnoux, F. Djojo, J.-L. Reymond, Angew. Chem. Int. Ed. 2003, 42, 1381-1383.

68. Fluorogenic Stereochemical Probes for Transaldolases. E. González-García, V. Helaine, G. Klein, M. Schuermann, G. A. Sprenger, W.-D. Fessner, J.-L. Reymond, Chem. Eur. J. 2003, 9, 893-899.


67. Detection Strategies for Catalytic Antibodies. J.-L. Reymond, J. Immunol. Methods 2002, 269, 125-131.

66. High-Throughput Screening of Thermostable Esterases for Industrial Bioconversions. D. Lagarde, H.-K. Nguyen, G. Ravot, D. Wahler, J.-L. Reymond, G.Hills, T. Veit, F. Lefevre, Org. Process. R. & D. 2002,6, 441-5.

65. A selective HIV-Protease Assay Based on a Chromogenic Amino Acid. F. Badalassi, H.-K. Nguyen, P. Crotti, J.-L. Reymond, Helv. Chim. Acta2002, 85, 3090-3098.

64. A structural basis for the activity of retro-Diels-Alder catalytic antibodies: Evidence for a catalytic aromatic residue. M. Hugot, N. Bensel, M. Vogel, M. T. Reymond, B. Stadler, J.-L. Reymond, U. Baumann, Proc. Natl. Acad. Sci. USA 2002, 99, 9674-8.

63. Enzyme Fingerprints of Activity, Stereo- and Enantioselectivity from Fluorogenic and Chromogenic Substrate Arrays. D. Wahler, F. Badalassi, P. Crotti, J.-L. Reymond, Chem. Eur. J. 2002, 8, 3211-3228.

62. Methylamine Adenine Dinucleotide (MAD), a Cofactor to Turn Alcohol Dehydrogenases into Aldolases. D. Wahler, J.-L. Reymond, Can. J. Chem.2002, 80, 665-670.

61. Substrate Arrays as Enzyme Fingerprinting Tools. J.-L. Reymond, D. Wahler, ChemBiochem 2002, 3, 701-708.

60. The Adrenaline Test for Enzymes. D. Wahler, J.-L. Reymond, Angew. Chem. Int. Ed. Engl.2002, 41, 1229-1232.


59. New High-Throughput Screening Assays for Biocatalysis. J.-L. Reymond, Chimia 2001, 55, 1049.

58. High-Throughput Screening for Biocatalysts. D. Wahler, J.-L. Reymond, Curr. Opin. Biotechnol. 2001, 12, 535.

57. Enzyme Fingerprints by Fluorogenic and Chromogenic Substrate Arrays. D. Wahler, F. Badalassi, P. Crotti, J.-L. Reymond, Angew. Chem. Int. Ed. Engl. 2001, 40, 4457.

56. Exploring Biocatalysis Using Catalytic Antibodies. J.-L. Reymond, Chimia 2001, 55, 330.

55. Aminocyclopentitol Inhibitors of a-L-Fucosidases. A. Blaser, J.-L. Reymond, Helv. Chim. Acta2001, 2119.

54. Pivalase Catalytic Antibodies: Towards Abzymatic Activation of Prodrugs. N. Bensel, M. T. Reymond, J.-L. Reymond, Chem. Eur. J. 2001, 7, 4604.

53. Enantioselective Epoxidation with a Library of Catalytic Antibodies. Y. Chen, J.-L. Reymond, Synthesis 2001, 934.

52. A Fluorescent Metal Sensor Based on Macrocyclic Chelation. G. Klein, D. Kaufmann, S. Schürch, J.-L. Reymond, Chem. Commun.2001, 561.

51. An Enzyme Assay using pM. G. Klein, J.-L. Reymond, Angew. Chem. 2001, 113, 1821.

50. Novel Methods for Biocatalysts Screening. D. Wahler, J.-L. Reymond, Curr. Opin. Chem. Biol. 2001, 5, 152.


49. A Versatile Periodate-Coupled Fluorogenic Assay for Hydrolytic Enzymes. F. Badalassi, D. Wahler, G. Klein, P. Crotti, J.-L. Reymond, Angew. Chem. Int. Ed.Engl. 2000, 39, 4067.

48. Stereoselective Inhibition of a-L-Fucosidases by N-Benzyl Aminocyclopentitols. A. Blaser, J.-L. Reymond, Org. Lett. 2000, 2, 1733.

47. Stereoselective Synthesis of an Aminocyclopentitol Analog of a-L-Fucose via an Allylic Bromohydrin. A. Blaser, J.-L. Reymond, Synlett 2000, 6, 817.

46. Fluorogenic Polypropionate Fragments for Detecting Stereoselective Aldolases. R. Pérez Carlón, N. Jourdain, J.-L. Reymond, Chem. Eur. J. 2000, 6, 4154.

45. Atropisomeric Transition State Analogs. O. Ritzeler, S. Parel, B. Therrien, N. Bensel, J.-L. Reymond, K. Schenk, Eur. J. Org. Chem. 2000, 1365.

44. Synthesis and Evaluation of Amino-Cyclopentitol Inhibitors of b -Glucosidases. O. Boss, E. Leroy, A. Blaser, J.-L. Reymond, Org. Lett. 2000, 2, 151.


43. Atropisomeric Transition State Analogs. O. Ritzeler, G. Klein, J.-L. Reymond, Phosphor Sulfur Silicon. 1999, 146, 243.

42. Anomer-selective Inhibition of Glycosidases using Amino-cyclopentanols. E. Leroy, J.-L. Reymond, Org. Lett. 1999, 1, 775.

41. Phosphofurylalanine, a Stable Analog of Phosphohistidine. C. Schenkels, B. Erni, J.-L. Reymond, Bioorg. Med. Chem. Lett. 1999, 1443.

40. A Selective a-L-Fucosidase Inhibitor Based on an Aminocyclopentane Framework. A. Blaser, J.-L. Reymond, Helv. Chim. Acta 1999, 82, 760.

39. Enantioselective Fluorogenic Assay of Acetate Hydrolysis for Detecting Lipase Catalytic Antibodies. G. Klein, J.-L. Reymond, Helv. Chim. Acta 1999, 82, 400.

38. Catalytic Antibodies by Fluorescence Screening. N. Bensel, N. Bahr, M. T. Reymond, C. Schenkels and J.-L. Reymond, Helv. Chim. Acta 1999, 82, 44.

37. A General Fluorogenic Assay for Catalysis Using Antibody Sensors. P. Geymayer, N. Bahr and J.-L. Reymond, Chem. Eur. J. 1999, 5, 1006.

36. Catalytic Antibodies for Organic Synthesis. J.-L. Reymond, Top. Curr. Chem. 1999, 200, 59.


35. A Stereoselective Fluorogenic Assay for Aldolases: Detection of an anti-selective Aldolase Catalytic Antibody. N. Jourdain, R. Pérez-Carlón, J.-L. Reymond, Tetrahedron Lett. 1998, 39, 9415.

34. Enantioselectivity vs. Kinetic Resolution in Antibody Catalysis: Formation of the (S) product despite preferential binding of the (R) Intermediate. D. Shabat, H. Shulman, H. Itzhaky, J.-L. Reymond, E. Keinan, Chem. Commun. 1998, 1759.

33. Stereoselectivity of Aldolase Catalytic Antibodies. J.-L. Reymond, J. Mol. Cat. B 1998, 5, 331.

32. An Enantioselective Fluorimetric Assay for Alcohol Dehydrogenases Using Albumin-Catalyzed b-Elimination of Umbelliferone. G. Klein, J.-L. Reymond, Bioorg. Med. Chem. Lett. 1998, 8, 1113.

1988 - 1997

31. Design and Synthesis of Transition State Analogs for Induction of Hydride Transfer Catalytic Antibodies. J. Schröer, M. Sanner, J.-L. Reymond, R. A. Lerner, J. Org. Chem. 1997, 62, 3220.

30. Highly Photoresistant Chemosensors Using Acridone as Fluorescent Label. N. Bahr, E. Tierney, J.-L. Reymond, Tetrahedron Letters 1997, 38, 1489.

29. Asymmetric Organic Synthesis with Catalytic Antibodies. E. Keinan, S. C. Sinha, D. Shabat, H. Itzhaky, J.-L. Reymond, Acta Chem. Scand. 1996, 50, 679.

28. Antibody-Catalyzed Uni- And Multi-Substrate Reactions Compared Using Transition State Binding (KTS). J.-L. Reymond, Y. Chen, Isr. J. Chem. 1996, 36, 199.

27. Catalytic Antibodies as Probes of Evolution: Modelling of a Primordial Glycosidase. D. Shabat, S. C. Sinha, J.-L. Reymond, E. Keinan, Angew. Chem. Intl. Ed. Engl.1996, 35, 2628.

26. A Nitroxyl Synthase Catalytic Antibody. N. Bahr, R. Güller, J.-L. Reymond, R. A. Lerner, J. Am. Chem. Soc. 1996, 118, 3550.

25. A General Assay for Antibody Catalysis using Acridone as a Fluorescent Tag. J.-L. Reymond, T. Koch, J. Schröer, E. Tierney, Proc. Natl. Acad. Sci. USA 1996, 93, 4251.

24. Catalytic, Enantioselective Aldol Reaction with an Artificial Aldolase Assembled from a Primary Amine and an Antibody. J.-L. Reymond, Y. Chen, J. Org. Chem. 1995, 6970.

23. Antibody Catalysis of Multistep Reactions: an Aldol Addition Followed by a Disfavored Elimination. T. Koch, J.-L. Reymond, R. A. Lerner, J. Am. Chem. Soc. 1995, 117, 9383.

22. (S)-Enantioselective Retroaldol Reaction and (R)-Enantioselective b-Elimination with an Aldolase Catalytic Antibody. J.-L. Reymond, Angew. Chem. Int. Ed. Engl. 1995, 34, 2285.

21. Epoxidation of Olefins with Formamide - Hydrogen Peroxide. Y. Chen, J.-L. Reymond, Tetrahedron Letters 1995, 36, 4015.

20. Catalytic, Enantioselective Aldol Reaction Using Antibodies against a Quaternary Ammonium Ion with a Primary Amine Cofactor. J.-L. Reymond, Y. Chen, Tetrahedron Letters 1995, 36, 2575.

19. Antibody Catalysis of a Reaction Otherwise Strongly Disfavored in Water. D. Shabat, H. Itzhaky, J.-L. Reymond, E. Keinan, Nature 1995, 374, 143.

18. Structure of the Antibody - Transition State Complex and Origin of the Enantioselectivity. G. K. Jahangiri, J.-L. Reymond, J. Am. Chem. Soc. 1994, 116, 11264.

17. An Antibody-Catalyzed 1,2-Rearrangement of Carbon-Carbon Bonds. Y. Chen, J.-L. Reymond, R. A. Lerner, Angew. Chem. Int. Ed. Engl. 1994, 33, 1607.

16. Enantioselective, Multigram-Scale Synthesis with a Catalytic Antibody. J.-L. Reymond, J.-L. Reber, R. A. Lerner, Angew. Chem. Int. Ed. Engl. 1994, 33, 475.

15. Antibody-Catalyzed Activation of Unfunctionalized Olefins for Highly Enantioselective Asymmetric Epoxidation. A. Koch, J.-L. Reymond, R. A. Lerner, J. Am. Chem. Soc. 1994, 116, 803.

14. Antibody-Catalyzed Reversal of Chemoselectivity. S. C. Sinha, E. Keinan, J.-L. Reymond, Proc. Natl. Acad. Sci. USA 1993, 90, 11910.

13. Antibody-Catalyzed Enantioselective Epoxide Hydrolysis. S. C. Sinha, E. Keinan, J.-L. Reymond, J. Am. Chem. Soc. 1993, 115, 4893.

12. Antibody-Catalyzed Hydrolysis of Enol Ethers. J.-L. Reymond, G. K. Jahanghiri, R. A. Lerner, J. Am. Chem. Soc. 1993, 115, 3909.

11. Highly Enantioselective Protonation Catalyzed by an Antibody. J.-L. Reymond, K. D. Janda, R.A. Lerner, J. Am. Chem. Soc. 1992, 114, 2257.

10. Antibody Catalysis of Glycosidic Bond Hydrolysis. J.-L. Reymond, K. D. Janda, R. A. Lerner, Angew. Chem. Int. Ed. Engl. 1991, 30, 1711.

9. Highly Stereoselective Synthesis of (+/-)-Aminobromocyclitol Derivatives from Furan. E. Reynard, J.-L. Reymond, P. Vogel, Synlett 1991, 470.

8. Total, Asymmetric Syntheses of (+)-Castanospermine, (+)-6-Deoxycastanospermine and (+)-6-Deoxy-6-fluorocastanospermine. J.-L. Reymond, A. A. Pinkerton, P. Vogel, J. Org. Chem. 1991, 56, 2128.

7. Stereoselective Syntheses of Protected Amino-hydroxy-cyclopentane-carbaldehyde Derivatives from 7-Oxabicyclo[2.2.1]hept-5-en-2-yl Systems. J.-L. Reymond, P. Vogel, Chimia 1990, 44, 342.

6. New Chiral Auxiliaries and New Optically Pure Ketene Equivalents Derived from Tartaric Acids. Improved Synthesis of (-)-7-Oxabicyclo[2.2.1]hept-5-en-2-one. J.-L. Reymond, P. Vogel, Tetrahedron: Asymmetry 1990, 1, 729.

5. Application of New Optically Pure Ketene Equivalents Derived from Tartaric Acids to the Total, Asymmetric Syntheses of (+)-6-Deoxycastanospermine and (+)-6-Deoxy-6-fluoro castanospermine. J.-L. Reymond, P. Vogel, J. Chem. Soc. Chem. Commun. 1990, 1070.

4. Acid Promoted Rearrangements of N-Substituted 8-Oxa-3-azatricyclo[,4]octane-6,7-dicarboxylates: Remote Substituent Effects on the Regioselectivity of the N-Acylaziridine/dihydrooxazone Rearrangement. S. Allemann, J.-L. Reymond, P. Vogel, Helv. Chim. Acta 1990, 73, 674.

3. Acid-catalyzed Rearrangements of 3-Aza-8-oxabicyclo[,4]oct-6-one Acetals. Highly Stereoselective Total Synthesis of 3-Amino-3-deoxy-D-altrose and Derivatives. C. Nativi, J.-L. Reymond, P. Vogel, Helv. Chim. Acta 1989, 72, 882.

2. A highly Stereoselective Synthesis of Castanospermine. J.-L. Reymond, P. Vogel, Tetrahedron Letters 1989, 30, 705.

1. Stereoselective amino-hydroxylation of the double bond in 7-oxabicyclo[2.2.1]hept-5-en-2-yl derivatives. Remote substituent participation in acid-catalyzed decompositions of aziridines and triazolines. J.-L. Reymond, P. Vogel, Tetrahedron Letters 1988, 29, 3695.

Ph.D.-theses with Prof. Reymond


47. Ricardo Visini, 2017. Cheminformatic and structural biology insights into small molecule fragments, ring systems and peptides.


46. Runze He, 2016. Design of short cyclic and linear antimicrobial peptides targeting multi-drug resistant bacteria.

45. Xian Jin, 2016. Molecular Fingerprints for the Analysis of Proteins in 3D-shape Space and Their Application for Peptide Design.


44. Gaëlle Michaud, 2015. Exploration of Multivalent Glycopeptide Dendrimers as Inhibitors against Pseudomonas aeruginosa Biofilms.

43. Falco Kilchmann, 2015. Novel Inhibitors for the Kinase Aurora-A.

42. Céline Simonin, 2015. Targeting Ion Channels and Transporters with Small Molecules: an Integrated Virtual Screening and Synthesis Approach.

41. Mahendra Awale, 2015. Interactive Chemical Space Visualization and Virtual Screening for Drug Discovery.


40. Marco Bartoloni, 2014. Design, synthesis and structure analysis of bicyclic bridged peptides.

39. Michaela Stach, 2014. Discovery and Optimization of Antimicrobial Peptide Dendrimers against Pseudomonas aeruginosa.

38. Julian Schwartz, 2014. New Tools and Methods for Virtual Screening of Small Molecules and Peptides.

37. Myriam Bergmann, 2014. Multivalent Glycopeptide Dendrimers as Pseudomonas aeruginosa Biofilm Inhibitors.


36. Justus Bürgi, 2013. Design, Synthesis and Characterization of Small Molecules Modulating Nicotinic Acetylcholine Receptors.

35. Gabriela Andrea Eggimann, 2013. Peptide Dendrimers with Cell Penetrating and Gene Transfection Properties.

34. Lars Ruddigkeit, 2013. Assembly, Analysis and Application of the Chemical Universe Database GDB-17.


33. Nicolas Uhlich, 2011. Convergent Synthesis of Protein-Sized Peptide Dendrimers.

32. Rasomoy Biswas, 2011. Glycopeptide Dendrimers for Drug Delivery and a Comparative Esterase Activity Study between Linear and Dendritic Peptides.

31. Lorenz Christian Blum, 2011. Assembly, Analysis and Application of the Chemical Universe Database GDB-13.

30. Rameshwar Kadam, 2011. Structure and Dynamics of Peptide Dendrimers.


29. Erika Luethi, 2010. Mining the Chemical Universe Database GDB for New Bioactive Aspartate, Glutamate and Peptide Analogues.

28. Ruud van Deursen, 2010. Computation Methods for Mapping and Scoring Chemical Space towards Drug Discovery.#

27. Noélie Maillard, 2010. Development of an Off-Bead Screening to Discover Catalysts and New Antimicrobial Peptide Dendrimers

26. Viviana S. Fluxa Rojas, 2010. Combinatorial Discovery of Antimicrobial Cyclic Peptide Analogues of Tyrocidine A, Gramicidin S and Daptomycin.


25. Kong Thong Nguyen, 2009. Ligand Discovery from the Chemical Universe Database

24. Emma M. V. Johansson, 2009. Combinatorial Discovery of Glycopeptide Dendrimers Targeting Lectins.


23. Sacha Javor, 2008. Peptide Dendrimers as Enzyme Mimics.


22. Peter Sommer, 2007. Combinatorial Discovery and Investigation of Peptide Dendrimers Models for the Vitamin B12 and Heme Binding Proteins.

21. Salahuddin Syed, 2007. Synthesis and Discovery of Bioactive Small Molecule from the Chemical Universe Database (GDB).


20. Peter Babiak, 2006. Lipase and esterase screening and fingerprinting.

19. Jacob Kofoed, 2006. Peptide Dendrimers and Zinc-Proline as Artificial Aldolases: Mimicking Nature's Approach to Carbon-Carbon Bond Formation.

18. Renaud Sicard, 2006.
Part I: New high-throughput screening and fingerprinting assays for microbial enzymes. Part II: Evaluation of cytotoxic glycopeptide dendrimer conjugates of Taxol and Colchicine.

17. Tobias Fink, 2006. The Chemical Universe of Small Molecules.


16. Johann Grognux, 2005. Fluorescence Assays for Fingerprinting Lipases in Solution and on Microarray.

15. Anthony Clouet, 2005. Discovery of New Functional Peptide Dendrimers as Enantioselective Catalyts and Hosts for Vitamin B12.

14. Estelle Delort, 2005. Catalytic Peptide Dendrimers as Artificial Enzymes: from Rational Design to Combinatorial Approach.

13. Yongzheng Yang, 2005. Enzyme Activity Fingerprinting with Peptide Cocktail and Substrate Cocktail.


12. David Lagnoux, 2004. Glycopeptide Dendrimer Drug Conjugates.

11. Lucas Gartenmann, 2004. Synthesis and Activity of Glycosidase Inhibitors and their Use as Haptens.


10. Lei Zheng, 2003. Structure and Function Relationships of Catalytic Antibodies Studied by X-Ray Crystallography and Site-Directed Mutagenesis and Computer Modelling.


9. Eva-Maria Gonzalez Garcia 2002. Synthesis of New Fluoro / Chromogenic Enzyme Substrates and Implementation in Screening Transaldolases and Lipases.

8. Marina Hugot, 2002. Structure-Activity Relationships in Nitroxyl-Synthase Catalytic Antibodies.

7. Emmanuel Leroy, 2002. Design and Synthesis of New α –andβ-Galactosidase Inhibitors.

6. Denis Wahler, 2002. Substrate Arrays for Enzyme Fingerprinting.


5. Caroline Schenkels, 2001. Chemistry and Biology of Phosphohistidine Analogs.

4. Nathalie Jourdain, 2001. Chemical Approaches for the Design, Screening and Selection of Artificial Biocatalysts.

3. Gérard Klein, 2001. Cinq Nouvelles Méthodes de Criblage ?Haut Débit pour des Enzymes Enantiosélectives et leur Application aux Anticorps Catalytiques.

2. Nicolas Bensel, 2001. Activation de Prodrogues du NO par les Anticorps Catalytiques.

1. Adrian Blaser, 2001. Aminocyclopentitol Inhibitors of α-L-Fucosidase and their Use as Haptens.